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Their blood samples were collected on the 3rd day of the menstrual cycle to measure 5\u2010hydroxytryptamine, renin, norepinephrine, angiotensin II and cortisol. Salivary amylase was obtained on the embryo transfer day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with normal women who came to the hospital for regular physical examination, the incidence of anxiety and depression was higher in women seeking for IVF treatment. After psychological intervention, the condition got improved and the incidence of anxiety and depression was 6.25% and 7.81% separately in these women. There were no significant differences between the anxiety scores in women with and without pregnancy. The depression scores did show some statistically differences, with higher scores in the nonpregnancy group. The level of 5\u2010hydroxytryptamine, renin, norepinephrine and cortisol were not significantly different between the two groups, while angiotensin II and salivary amylase seemed to be negatively correlated with pregnancy outcome. Simultaneously, a positive correlation was found between angiotensin II and anxiety and depression scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Depression during IVF has a negative impact on pregnancy outcome. The measurement of angiotensin II and salivary amylase might be reference index for the psychological status of patients during IVF\u2010ET.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14278","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T07:50:40Z","timestamp":1591343440000},"page":"1355-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prospective study of pregnancy outcome between perceived stress and stress\u2010related hormones"],"prefix":"10.1111","volume":"46","author":[{"given":"Yuqian","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Cheeloo college of Medicine, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongling","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Cheeloo college of Medicine, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanwei","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Cheeloo college of Medicine, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Cheeloo college of Medicine, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-9808","authenticated-orcid":false,"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital, Cheeloo college of Medicine, Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_2_7_3_1","unstructured":"European Society of Human Reproduction and Embryology. 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