{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:10Z","timestamp":1747186510421,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detectable serum levels of beta subunit of human chorionic gonadotropin (\u03b2hCG) in nonpregnant, perimenopausal women bring confusion in both clinician and patient and could lead to unnecessary diagnostic and therapeutic procedures. A 45\u2010year\u2010old woman with the continuous elevation of \u03b2hCG underwent hysteroscopy, two laparoscopic surgeries, two explorative uterine cavity curettages and three cycles of cytostatic therapy. No ultrasonographic, macroscopic or histological signs of pregnancy, both uterine and ectopic or gestational trophoblastic disease were found. Both radiographic and computed tomography reports ruled out the presence of a nongynecological neoplasm. All recommended steps were taken for confirmation or ruling out the possibility of heterophile antibodies interference, but the results were not absolute. Finally, the referent laboratory confirmed the presence of the antibodies, but their exact type remains unknown. This case underlines the importance of the universally accepted protocol in the cases of persistent \u03b2hCG elevation in nonpregnant, perimenopausal women.<\/jats:p>","DOI":"10.1111\/jog.14312","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T06:34:15Z","timestamp":1591338855000},"page":"1465-1469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report of persistent elevation of <scp>\u03b2hCG<\/scp> in a nonpregnant woman: A diagnostic puzzle"],"prefix":"10.1111","volume":"46","author":[{"given":"Branka","family":"Nikoli\u0107","sequence":"first","affiliation":[{"name":"School of Medicine University of Belgrade  Belgrade Serbia"},{"name":"The Obstetrics and Gynaecology Clinic Narodni Front  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-0311","authenticated-orcid":false,"given":"Aleksandar","family":"Raki\u0107","sequence":"additional","affiliation":[{"name":"The Obstetrics and Gynaecology Clinic Narodni Front  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Ardali\u0107","sequence":"additional","affiliation":[{"name":"The Obstetrics and Gynaecology Clinic Narodni Front  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Cimbaljevi\u0107","sequence":"additional","affiliation":[{"name":"The Obstetrics and Gynaecology Clinic Narodni Front  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000281557.04956.61"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218807"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102037"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000492"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12615"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/580709"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.05.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-19"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5301\/ijbm.5000290"},{"key":"e_1_2_5_11_1","first-page":"159","volume-title":"Advances in Experimental Medicine and Biology","author":"Sisinni L","year":"2015"},{"key":"e_1_2_5_12_1","first-page":"107815521989428","article-title":"Elevated beta human chorionic gonadotropin in a non\u2010pregnant female diagnosed with anal squamous cell carcinoma","author":"Pokharel K","year":"2019","journal-title":"J Oncol Pharm Pract"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2015.11.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-1142"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.12.018"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm.2011.808"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(09)60203-5"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.14312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:40:01Z","timestamp":1693914001000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/jog.14312"],"URL":"https:\/\/doi.org\/10.1111\/jog.14312","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2020,6,4]]},"assertion":[{"value":"2020-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}