{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T02:13:47Z","timestamp":1722392027713},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Growth\u2010restricted fetuses have delayed rhythm formation in utero. The awake\u2013sleep cycle of fetal heart rate pattern is thought to represent fetal rhythm. We aimed to study if the emergence of rhythm formation on fetal heart rate pattern delays in fetal growth restriction compared to appropriate\u2010for\u2010date fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study including 75, normal\u2010structured, singleton fetuses. Of them, 21 were fetal growth restriction and the remaining 54 were appropriate\u2010for\u2010date infants. We examined timing of emergence of rhythm formation on fetal heart rate pattern comparing between fetal growth restriction and appropriate\u2010for\u2010date fetuses after adjusting possible confounding factors as outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rhythm formation was significantly delayed in fetal growth restriction (&lt;10th percentile) compared to the appropriate\u2010for\u2010date subgroups (10\u201330, 30\u201350, 50\u201370 and 70\u201390th percentile) by 1\u20132\u2009weeks. After adjusting confounding factors, growth restriction was the only independent variable to delay fetal rhythm formation. One infant for each group had neurodevelopmental disorder and the incidence did not reach statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on fetal heart rate pattern analysis, growth\u2010restricted fetuses show 1\u20132\u2009weeks delay in rhythm formation compared to appropriate\u2010for\u2010date fetuses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14316","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T23:54:50Z","timestamp":1590710090000},"page":"1342-1348","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Delayed rhythm formation of normal\u2010structured, growth\u2010restricted fetuses using fetal heart rate monitoring patterns"],"prefix":"10.1111","volume":"46","author":[{"given":"Kaeko","family":"Sumiyoshi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanao","family":"Ohhashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sameshima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyomu","family":"Ikenoue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Center for Perinatal Medicine University of Miyazaki Faculty of Medicine  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