{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:11:43Z","timestamp":1774642303566,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of 25\u2009\u03bcg of estradiol gel on postmenopausal vaginal tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized double\u2010blind controlled trial included postmenopausal women with vaginal atrophy who attended our menopause clinic during July 2017\u2013January 2018. Women were randomly assigned to the estradiol gel group or control group (K\u2010Y\u00ae Jelly). Treatment consisted of 2\u2009mL of product applied intravaginally daily for 2\u2009weeks, and two doses per week for the next 6\u2009weeks. The most bothersome symptom (MBS), vaginal health index (VHI), vaginal pH, vaginal maturation index, vaginal maturation value (VMV), female sexual function index (FSFI), serum estradiol level and endometrial thickness were evaluated at baseline, 4 and 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five of 80 women completed the trial. After 8\u2009weeks of treatment, VMV, VHI, vaginal pH and FSFI improved significantly in the estradiol group, with no observed change in the control group. The MBS was decreased in both groups with no significant difference between groups. Serum estradiol level and endometrial thickness were not significantly different between groups at baseline or at week 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Estradiol vaginal gel demonstrated an ability to reverse vaginal atrophy with a high safety profile and low systemic absorption of estradiol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14336","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:20:07Z","timestamp":1595809207000},"page":"1425-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of estradiol vaginal gel on vaginal atrophy in postmenopausal women: A randomized double\u2010blind controlled trial"],"prefix":"10.1111","volume":"46","author":[{"given":"Prasong","family":"Tanmahasamut","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titima","family":"Jirasawas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Vachira Hospital Navamindradhiraj University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"Laiwejpithaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatchai","family":"Areeswate","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongdee","family":"Dangrat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittayaporn","family":"Silprasit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a95581"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1139\/w05-070"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00240-8"},{"key":"e_1_2_7_5_1","first-page":"245","article-title":"Vaginal dryness in the menopausal woman (physiological and psychological aspects)","volume":"28","author":"Rossin\u2010Amar B","year":"2000","journal-title":"Gynecol Obstet Fertil"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.647840"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2001.tb01266.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/154099902762203704"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00298-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001446"},{"key":"e_1_2_7_12_1","unstructured":"Product information. 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