{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:16:34Z","timestamp":1770700594956,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the feasibility and outcome of intrauterine transfusion (IUT) for the surviving co\u2010twin in monochorionic diamniotic (MCDA) twin gestations involving single intrauterine fetal death (sIUFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of MCDA twin gestations involving emergent IUT for co\u2010twins experiencing acute feto\u2010fetal hemorrhage (AFFH) subsequent to sIUFD during the second trimester were reviewed. Fetal anemia was confirmed via fetal blood sampling, and perinatal data were retrieved from medical charts to determine the outcomes of surviving co\u2010twins. A poor outcome at 28\u2009days of age was defined as fetal death, neonatal death or neurological impairment such as severe intraventricular hemorrhage or cystic periventricular leukomalacia (PVL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included 16 cases of sIUFD diagnosed at a median of 22.5\u2009weeks of gestation (range: 18\u201325\u2009weeks). The median interval in hours between diagnosis of fetal demise and IUT was approximately 4.2 (0\u201322) hours. All cases achieved IUT without significant intraoperative complications. Four cases experienced a fetal loss of the co\u2010twin, whereas 12 co\u2010twins were born alive (including 9 preterm births), with only 1 poor outcome in a preterm infant with PVL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IUT may be a feasible prenatal intervention for surviving co\u2010twins with AFFH. However, more extensive or pooled studies are needed to determine the efficacy of this intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14338","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T10:54:55Z","timestamp":1591095295000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Perinatal outcomes of intrauterine transfusion for the surviving twin in monochorionic twin gestation involving a single fetal demise"],"prefix":"10.1111","volume":"46","author":[{"given":"Masako","family":"Kanda","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Women's and Children's Hospital  Izumi Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Maternal and Perinatal Care Center Seirei Hamamatsu General Hospital 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