{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:05:45Z","timestamp":1781276745075,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005716","name":"Babol University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Endometrial mesenchymal stem cells (eMSC) have a vital role in regeneration of endometrium during menstrual cycles. Since it has been suggested that (eMSC) likely play a role in uterine receptivity and establishment of pregnancy, we aimed to evaluate the expression levels of five most known receptivity markers\u2010Integrin (ITG) \u03b21, Rac1, HoxA11, ITG\u03b23 and Noggin\u2010in eMSC of recurrent implantation failure (RIF) and non\u2010RIF women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human eMSC were isolated from menstrual blood (MB) of RIF and non\u2010RIF women. The isolated eMSC characterized based on their morphological and behavioral characteristics, expression of MSC\u2010specific surface CD markers and their capacity of differentiation into osteocytes and adipocytes. The expression levels of the five mentioned receptivity markers were analyzed with real time reverse transcription polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings revealed that RIF and non\u2010RIF eMSC expressed all tested genes at different levels. ITGb1 expression in RIF eMSC was lower than its expression in non\u2010RIF cells. On the other hand, all the other markers were expressed at higher levels in RIF eMSC than in non\u2010RIF cells although only HOXA11 and ITG \u03b23 showed statistically significant (<jats:italic>P<\/jats:italic> &lt;\u20090.05) higher expression levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot study on determination of the expression levels of uterine receptivity markers in eMSC interestingly indicated that RIF and non\u2010RIF eMSC were different regarding the expression of these markers. Future studies using these findings can brighten up more the role of eMSC in the endometrium receptivity and establishment of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14340","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T23:11:39Z","timestamp":1591139499000},"page":"1393-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Receptivity markers in endometrial mesenchymal stem cells of recurrent implantation failure and <scp>non\u2010<\/scp>recurrent implantation failure women: A pilot study"],"prefix":"10.1111","volume":"46","author":[{"given":"Sedighe","family":"Esmaeilzadeh","sequence":"first","affiliation":[{"name":"Infertility and Reproductive Health Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Infertility and Reproductive Health Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Mahdinejad","sequence":"additional","affiliation":[{"name":"Infertility and Reproductive Health Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"Infertility and Reproductive Health Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ghasemzadeh\u2010Hasankolaei","sequence":"additional","affiliation":[{"name":"Infertility and Reproductive Health Research Center, Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq061"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X637362"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328235a5c6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.1.81"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1130-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-5-57"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-45"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3573846"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806219105"},{"key":"e_1_2_7_11_1","unstructured":"Global prevalence of infertility infecundity and childlessness. 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