{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T14:08:36Z","timestamp":1786457316204,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601315"],"award-info":[{"award-number":["81601315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HM02"],"award-info":[{"award-number":["ZR2016HM02"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore whether neutrophil\u2010to\u2010lymphocyte ratio (NLR) and monocyte\u2010to\u2010lymphocyte ratio (MLR) could predict missed abortion (MA) at 7\u201313\u2009week's gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 363 women with a diagnosis of MA and 232 women with normal pregnancy at 7\u201313\u2009week's gestation, who visited our hospital from June 2012 to May 2018 were retrospectively analyzed. At 7\u2009week's gestation, total and differential leukocyte counts, NLR and MLR were compared between women with MA (<jats:italic>n<\/jats:italic> = 69) and normal controls (<jats:italic>n<\/jats:italic> =\u200953). The receiver operating characteristic curve was used to select the optimal indicator and its cut\u2010off point. The role of the optimal indicator was further assessed at 8\u201313\u2009week's gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean white blood cell counts, the mean neutrophil counts, the median monocyte counts, the mean NLR and the median MLR in women with MA were significantly lower than those in normal controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, respectively).The neutrophil counts had the highest area under the curve (AUC) value of 0.772 (95% confidence interval 0.675\u20130.869) with a cut\u2010off value of 4.870\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, and the sensitivity was 72.46%, the specificity was 69.81%, positive predictive value was 75.76%, and negative predictive value was 66.07%. In addition, the neutrophil counts were also significantly lower in MA groups than those in normal controls at 8\u201313\u2009week's gestation, and all had the highest AUC values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neutrophil counts may predict MA in the first trimester of pregnancy, which may provide a promising marker to diagnose missed abortion as early as 7\u2009week's gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14349","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:19:10Z","timestamp":1593130750000},"page":"1702-1710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Can neutrophil\u2010to\u2010lymphocyte and monocyte\u2010to\u2010lymphocyte ratios be useful markers for predicting missed abortion in the first trimester of pregnancy?"],"prefix":"10.1111","volume":"46","author":[{"given":"Qingjie","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, Qilu Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University  Jinan 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