{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:46:39Z","timestamp":1790754399932,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation for Women's Cancer Ovarinnavate: Ovarcome Research Excellence Award"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Precancer identification of women with hereditary breast and ovarian cancer (HBOC) could prevent 20% of these ovarian cancers. The objective was to determine whether standardized Facing Our Risk of Cancer Empowered (FORCE) materials are acceptable, improve knowledge of HBOC and increase disclosure to family members.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort of women with breast or ovarian cancer was identified prior to genetic testing. Subjects completed a baseline knowledge survey and were provided three communication aids. Knowledge, acceptability and communication to family members were reassessed at 6\u2009months and compared to a retrospective cohort who had undergone genetic testing for breast or ovarian cancer prior to the intervention. The primary outcome was increase in HBOC knowledge, requiring 20 pre\u2010 and postknowledge scores to detect a 10% difference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty women were enrolled. The median age at cancer diagnosis was 50\u2009years and 55% had a family history of breast or ovarian cancer. Though subjects found the resources acceptable, knowledge scores did not improve after their use. Disclosure rates were of no different between cohorts (83% preintervention vs 77% postintervention,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.26) though there was an increase in deleterious mutation carriers, 0% (0\/6) preintervention vs 100% (22\/22) postintervention. Rates of subsequent testing in relatives were low in both preintervention and postintervention cohorts (0% vs 4.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inclusion of standardized communication tools is acceptable to patients. Knowledge did not improve after their use. In deleterious mutation carriers, disclosure rates increased postintervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.14366","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T21:58:32Z","timestamp":1594591112000},"page":"1835-1841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mechanisms to increase cascade testing in hereditary breast and ovarian cancer: Impact of introducing standardized communication aids into genetic counseling"],"prefix":"10.1111","volume":"46","author":[{"given":"Christine","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology University of Virginia  Charlottesville Virginia USA"},{"name":"Kaiser San Francisco, 2238 Geary Blvd, San Francisco  CA 94114, 415\u2010833\u20104199 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie W.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Lothamer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Chatfield","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Cancer Genetics Emily Couric Cancer Center, University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Modesitt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncology University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115052108"},{"key":"e_1_2_8_3_1","unstructured":"National Comprehensive Cancer Network. NCCN guidelines for detection prevention & risk reduction: Genetic\/familial high\u2010risk assessment: Breast and ovarian. [Cited 13 Apr 2016.] Available from URL:http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/genetics_screening.pdf"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.009"},{"key":"e_1_2_8_5_1","unstructured":"SEER Stat Fact Sheets: Ovarian cancer. [Cited 31 Jul 2016.] Available from URL:http:\/\/seer.cancer.gov\/statfacts\/html\/ovary.html"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.6642"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2340"},{"key":"e_1_2_8_9_1","unstructured":"KarenL ElizabethS. Genetic counseling testing and treatment decisions: A moving target. 15 Oct 2013. 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[Cited 31 Jul 2016.] Available from URL:http:\/\/www.facingourrisk.org\/index.php"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.2.148"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530480027036"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1897-4287-10-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.231"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","unstructured":"HoskinsP EcclestonA HurryM DyerM.Targeted surgical prevention of epithelial ovarian cancer is cost effective and saves money in BCA mutation carrying family members of women with epithelial ovarian cancer. 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