{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:44:31Z","timestamp":1766137471370},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the effect of dexamethasone combined with metronidazole in the treatment of mammary duct ectasia (MDE) and its relationship with changes in serum interleukin\u201010 (IL\u201010) and IL\u201017 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty patients with MDE were divided into two groups randomly, control and observation groups (each <jats:italic>n<\/jats:italic> = 60). Another 50 patients with normal physical examination were recruited in the normal group. The expressions of serum IL\u201010 and IL\u201017 in three groups before and after treatment were observed. The prediction value of IL\u201010 and IL\u201017 in clinical efficacy was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among three groups, the expression of IL\u201010 in the normal group was the highest (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but the expression of IL\u201017 was the lowest (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). After treatment, the expression of IL\u201017 in observation group was lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), the expression of IL\u201010 was higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) than that in the control group. The areas under the IL\u201010 and IL\u201017 curve were 0.874 and 0.806, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dexamethasone combined with metronidazole can effectively improve the clinical efficacy of MDE patient treatment and serum IL\u201010 and IL\u201017 can be used as potential predictors of treatment efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14380","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T05:37:08Z","timestamp":1596001028000},"page":"2134-2141","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dexamethasone combined metronidazole on mammary duct ectasia and its relationship with serum <scp>IL<\/scp>\u201010 and <scp>IL<\/scp>\u201017"],"prefix":"10.1111","volume":"46","author":[{"given":"Yuwen","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Maternity and Child Health Care of Zaozhuang  Zaozhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuandong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Maternity and Child Health Care of Zaozhuang  Zaozhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Zaozhuang Hospital of Zaozhuang Mining Group  Zaozhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanshen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Zaozhuang Hospital of Zaozhuang Mining Group  Zaozhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Maternity and Child Health Care of Zaozhuang  Zaozhuang 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