{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T04:06:15Z","timestamp":1773547575538,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030310151"],"award-info":[{"award-number":["2016A030310151"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the involvement and interrelationship of epithelial cell adhesion molecule (EpCAM) and epithelial\u2013mesenchymal transition (EMT) in endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples from 114 patients undergoing endometrial biopsy or operation for endometriosis and 23 premenopausal women undergoing endometrial biopsy for non\u2010endometriotic benign disease. Immunohistochemistry was used to detect expression level of EpCAM, E\u2010cadherin and N\u2010cadherin in endometrium from patients with (<jats:italic>n<\/jats:italic> = 24) and without endometriosis (<jats:italic>n<\/jats:italic> = 23), and in lesions from bowel (<jats:italic>n<\/jats:italic> = 46), peritoneal (<jats:italic>n<\/jats:italic> = 20) and ovarian (<jats:italic>n<\/jats:italic> = 24) endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the expression level of EpCAM, E\u2010cadherin and N\u2010cadherin, respectively, between endometrium from women with and without endometriosis (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). There was also no significant difference in the expression level of EpCAM, E\u2010cadherin and N\u2010cadherin, respectively, among lesions from the bowel, peritoneal and ovarian endometriosis (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). We found that the immunoreactivity of endometriotic epithelial cells to EpCAM and N\u2010cadherin was significantly higher than that of eutopic endometrium, but decreased to E\u2010cadherin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). According to the expression level of EpCAM, the expression level of E\u2010Cadherin was significantly lower in endometriotic lesions with EpCAM expression above the mean level compared with that of endometriotic lesions with EpCAM expression below mean level, while the expression level of N\u2010cadherin was contrary (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). EpCAM staining level was negatively correlated with E\u2010cadherin but positively correlated with N\u2010cadherin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that overexpression of EpCAM, accompanied by an EMT, might be involved in endometriosis. EMT may be induced by the overexpression of EpCAM, thus promoting the development of endometriosis, which needs future studies to confirm for the pathogenesis of endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14401","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T06:36:05Z","timestamp":1595831765000},"page":"2066-2075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Increased expression of epithelial cell adhesion molecule and its possible role in epithelial\u2013mesenchymal transition in endometriosis"],"prefix":"10.1111","volume":"46","author":[{"given":"Duo","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Operating Room First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Yangtze River Pharmaceutical Group  Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1434.014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2017.6399"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2826"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071128"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc822"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2131"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des080"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107302913"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.042176"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603494"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj082"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.04.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0671-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24802"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.8540"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181a13bf2"},{"key":"e_1_2_7_23_1","first-page":"9110","article-title":"Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients","volume":"15","author":"Ma X","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i34.6315"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818794190"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2713"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181db7b84"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90389-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2013.01.002"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1335.036"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.04.009"},{"key":"e_1_2_7_32_1","first-page":"68","article-title":"The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes","volume":"1","author":"Valdes F","year":"2002","journal-title":"Mol Cancer Res"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01343-7"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der442"},{"key":"e_1_2_7_35_1","first-page":"461","article-title":"Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E\u2010cadherin","volume":"150","author":"Gaetje R","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63030-1"},{"key":"e_1_2_7_37_1","first-page":"355","article-title":"Transforming growth factor beta1 signaling coincides with epithelial\u2010mesenchymal transition and fibroblast\u2010to\u2010myofibroblast transdifferentiation in the development of adenomyosis in mice","volume":"31","author":"Shen M","year":"2016","journal-title":"Hum Reprod"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0236"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.10.025"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.03.029"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2683534"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S212478"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22410"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161212802430477"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2018-0274"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134858"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2019.06.005"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.03.004"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29252"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.011"},{"key":"e_1_2_7_51_1","first-page":"1678","article-title":"Epithelial cell adhesion molecule and epithelial\u2010mesenchymal transition are associated with vasculogenic mimicry, poor prognosis, and metastasis of triple negative breast cancer","volume":"12","author":"Wu Q","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0752"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4126"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0013-8"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.14401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:38:07Z","timestamp":1693960687000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,26]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jog.14401"],"URL":"https:\/\/doi.org\/10.1111\/jog.14401","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,26]]},"assertion":[{"value":"2019-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}