{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:27:26Z","timestamp":1791444446841,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The outbreak of the 2019 novel coronavirus disease (SARS\u2010CoV\u20102) has resulted in a major epidemic threat worldwide. However, the effects of neoviruses on infected pregnant women and especially on their fetuses and newborns are not well understood. Most up\u2010to\u2010date evidences about how SARS\u2010CoV\u20102 affected patients especially in pregnancy were collected by conducting a comprehensive search of medical literature electronic databases. Immune\u2010related data of pregnant women, fetuses and newborns were further analysis. According to the limited literature, SARS\u2010CoV\u20102 utilizes angiotensin converting enzyme 2 as its receptor and causes severe hypoxemia. Insufficiency of angiotensin converting enzyme 2 in pregnant women and the effects of hypoxia on the placental oxygen supply will cause severe perinatal complications. In addition, SARS\u2010CoV\u20102 infection may disrupt maternal\u2010fetal immune tolerance and cause immunological damage to embryos. Because of these reasons, pregnancy complications such as fetal demise or premature birth, preeclampsia, intrauterine growth restriction, respiratory dyspnea, nervous system dysplasia and immune system defects are likely to occur in pregnant women with COVID\u201019 or their newborns. Pregnant women infected with SARS\u2010CoV\u20102 should be treated as a special group and given special attention. Fetuses and newborns of SARS\u2010CoV\u20102\u2010infected pregnant women should be given more protection to reduce the occurrence of adverse events. In this review, we intend to provide an overview of the physiological and immunological changes that induce the pregnancy complications. This article will benefit the treatment and prognosis of fetuses and newborns of SARS\u2010CoV\u20102\u2010infected pregnant women.<\/jats:p>","DOI":"10.1111\/jog.14406","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:37:43Z","timestamp":1597106263000},"page":"1951-1957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Potential effects of <scp>SARS\u2010CoV<\/scp>\u20102 infection during pregnancy on fetuses and newborns are worthy of attention"],"prefix":"10.1111","volume":"46","author":[{"given":"Dan","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Neonatology First Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, College of Basic Medicine Jilin University  Changchun 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