{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:10:07Z","timestamp":1782886207443,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Tokishakuyakusan (TSS) is representative of popular Kampo medicines for Japanese women to treat dysmenorrhea, irregular menstruation and menopause. Current hormonal treatments and low\u2010dose oral contraceptives (OCs) used as a first\u2010choice drug for primary symptoms, however, have a high incidence of adverse events without improving patients' satisfaction. We evaluated the efficacy of TSS as additional treatment on the quality of life (QOL) of patients taking OCs with reduced therapeutic satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve patients treated with OCs for endometriosis were enrolled. TSS (7.5\u2009g\/day) in combination with OCs were given for three menstrual cycles. The main outcome was the degree of QOL assessed using the Endometriosis Health Profile\u201030 (EHP\u201030). Secondary outcomes were the Menstrual Distress Questionnaire (MDQ), patient's satisfaction using a Likert scale and cold feeling\u2010visual analogue scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In EHP\u201030, significant changes by TSS with OCs in each menstrual cycle were not found, although the scores for pain and emotional well\u2010being tended to decrease. In MDQ, water retention in the premenstrual phase was improved. With regard to cold feeling\u2010VAS, 61.6\u2009mm at pretreatment decreased to 31.3\u2009mm at the endpoint. Average Likert scale values after TSS treatment declined from 4.3 to 2.6. Cold feeling and patient's satisfaction have improved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the influence of TSS add\u2010on therapy on QOL was moderate, possible improvement of cold feeling and menstruation\u2010related symptoms was suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14424","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:09:28Z","timestamp":1598346568000},"page":"2280-2286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Tokishakuyakusan add\u2010on therapy with low\u2010dose oral contraceptive pills on endometriosis patients with dysmenorrhea"],"prefix":"10.1111","volume":"46","author":[{"given":"Fuminori","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University Faculty of Medicine  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Tokita","sequence":"additional","affiliation":[{"name":"Tsumura Kampo Research Laboratories Kampo Research and Development Division, Tsumura &amp; Co.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Gynecology Kurashiki Heisei Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University Faculty of Medicine  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University Faculty of Medicine  Yonago Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University Faculty of Medicine  Yonago 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