{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T17:11:46Z","timestamp":1746551506157},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyze whether radiological and pathological lymph node statuses affected prognosis in patients with epithelial ovarian cancer who underwent neoadjuvant chemotherapy followed by interval debulking surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 82 patients undergoing interval debulking surgery, including systematic retroperitoneal lymphadenectomy, were eligible for this study. We retrospectively analyzed the association among radiological diagnosed retroperitoneal lymphadenopathy by computed tomographic scan before (rLN) and after (yrLN) neoadjuvant chemotherapy, pathological lymph node metastasis (pLN) and prognosis. Patient survival distribution was calculated using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 36 rLN+ cases (44%); there were no significant differences between rLN+ and rLN\u2212 with respect to progression\u2010free survival and overall survival. Progression\u2010free survival and overall survival did not differ between yrLN+ cases and yrLN\u2212 cases. Thirty\u2010nine cases (47.5%) were pLN+, and both progression\u2010free survival and overall survival were significantly shorter in pLN+ cases than in pLN\u2212 cases (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic> = 0.004, respectively). In univariate analysis, FIGO stage, pLN and surgical completion were prognostic factors for overall survival. Moreover, in multivariate analysis, pLN+ was the independent prognostic factor for progression\u2010free survival (<jats:italic>P<\/jats:italic> = 0.001, 95% confidence interval: 1.911\u201315.69), and pLN and surgical completion were the only independent prognostic factors for overall survival (<jats:italic>P<\/jats:italic> = 0.046, <jats:italic>P<\/jats:italic> = 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Radiological lymph node status may not be a prognostic factor in patients with ovarian cancer who underwent neoadjuvant chemotherapy followed by interval debulking surgery. Pathological lymph node metastasis affects progression\u2010free survival and overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14446","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T02:20:11Z","timestamp":1598235611000},"page":"152-158","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of pretreatment radiological and pathological lymph node statuses on prognosis in patients with ovarian cancer who underwent interval debulking surgery with lymphadenectomy following neoadjuvant chemotherapy"],"prefix":"10.1111","volume":"47","author":[{"given":"Hiroaki","family":"Komatsu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University School of Medicine  Yonago Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University School of Medicine  Yonago Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiken","family":"Osaku","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University School of Medicine  Yonago Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruri","family":"Shimogai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University School of Medicine  Yonago Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chikumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University School of Medicine  Yonago Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tottori University 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