{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:32:13Z","timestamp":1787311933899,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study was designed to evaluate the effects of intrauterine transplantation of menstrual blood stem cells (MenSCs) on endometrial thickness and pregnancy outcomes in patients with refractory intrauterine adhesion (IUA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included a group of infertile women (\n                      <jats:italic>n<\/jats:italic>\n                      = 12, age 22\u201340\u2009years), with refractory IUA. Autologous MenSCs isolated from the women's menstrual blood were expanded\n                      <jats:italic>in vitro<\/jats:italic>\n                      and transplanted into their uteruses, followed by hormone replacement therapy. Transvaginal ultrasound examination was performed to assess the endometrial thickness. Transabdominal ultrasound was conducted to detect pregnancy outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Autologous MenSCs were successfully isolated and expanded from menstrual blood and transplanted into the uterus of each patient. A significant improvement of the endometrial thickness was observed from 3.9\u2009\u00b1\u20090.9 to 7.5\u2009\u00b1\u20090.6\u2009mm (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). No adverse reaction was observed. The duration of menstruation was increased from 2.4\u2009\u00b1\u20090.7 to 5.3\u2009\u00b1\u20090.6\u2009days (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Five out of 12 patients achieved clinical pregnancy and the pregnancy rate was 41.7%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intrauterine transplantation of autologous MenSCs results in regeneration of endometrium, a prolongation of menstrual duration and an increase rate of pregnancy in patients with refractory IUA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.14449","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T10:34:02Z","timestamp":1598610842000},"page":"2347-2355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Intrauterine transplantation of autologous menstrual blood stem cells increases endometrial thickness and pregnancy potential in patients with refractory intrauterine adhesion"],"prefix":"10.1111","volume":"46","author":[{"given":"Hailan","family":"Ma","sequence":"first","affiliation":[{"name":"Reproductive Center Guiping People's Hospital  Guiping China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Liu","sequence":"additional","affiliation":[{"name":"R&amp;D Center Wuhan Hamilton Biotechnology Co., Ltd  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive Center Guiping People's Hospital  Guiping 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