{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:30:06Z","timestamp":1791649806947,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy and safety of dinoprostone vaginal insert (PROPESS) in pregnant post\u2010term Japanese women requiring cervical ripening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled study included 114 pregnant Japanese women at term (41\u2009weeks of gestation) requiring cervical ripening (baseline Bishop score (BS)\u2009\u2264\u20094). The primary end\u2010point was the proportion of subjects with successful cervical ripening defined as BS\u2009\u2265\u20097 or vaginal delivery in 12\u2009h. The secondary end\u2010points were changes in BS, proportion of women with vaginal delivery, proportion of women receiving mechanical cervical ripening procedure and use of oxytocic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PROPESS administration for a maximum of 12\u2009h showed significantly higher successful cervical ripening rate (47.4% vs 14.3%, respectively; treatment contrast [TC]: 33.1%; <jats:italic>P<\/jats:italic> = 0.0002). The median time from administration to vaginal delivery was significantly shorter in the PROPESS group than in the placebo group (26.18\u2009h vs 33.02\u2009h; OR 2.51; 95% CI [1.60\u20133.92]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In the PROPESS group, the dosage of uterotonic drugs, such as oxytocin, decreased, and the number of patients who used these drugs also decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PROPESS administration for a maximum of 12\u2009h was an effective and well\u2010tolerated treatment for pregnant Japanese women post\u2010term requiring cervical ripening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14472","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T01:33:51Z","timestamp":1603416831000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy and safety of controlled\u2010release dinoprostone vaginal delivery system (<scp>PROPESS<\/scp>) in Japanese pregnant women requiring cervical ripening: Results from a multicenter, randomized, double\u2010blind, placebo\u2010controlled phase <scp>III<\/scp> study"],"prefix":"10.1111","volume":"47","author":[{"given":"Hiroaki","family":"Itoh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Higashi\u2010ku Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Ishii","sequence":"additional","affiliation":[{"name":"Osaka Women's and Children's Hospital  Izumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Rinku General Medical Center  Izumisanoshi Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Juntendo University  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hamada","sequence":"additional","affiliation":[{"name":"University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Itabashi Chuo Medical Center  Itabashi\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Bungyoku","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals Co. Ltd.  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Falahati","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals Co. Ltd.  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miori","family":"Tomisaka","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals Co. Ltd.  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiya","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Ferring Pharmaceuticals Co. Ltd.  Minato\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization. WHO recommendations for induction of labour.2011. 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