{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:31:38Z","timestamp":1767990698399,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulosa cell tumors of the ovary (GCT) are the most common type of sex cord stromal tumors. Although most of patients are diagnosed at early stage and has favorable 5\u2010year overall survival rate, 16\u201323% of GCT ultimately develop recurrent disease. Recurrences are characterized by disseminated peritoneal metastasis. The treatment options include systemic chemotherapy, secondary CRS or palliative localized radiation therapy have not yet standardized due to the rarity of disease. Aggressive CRS followed up by hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to provide benefit in other peritoneal disease but limited data available for recurrent GCT. We have a case of recurrent Adult\u2010type GCT (AGCT) who was treated with CRS followed by HIPEC with mitomycin C and doxorubicin. The patient has no evidence of recurrence for approximately 11\u2009years. An electronic search of the PubMed database with the following search terms: GCT, HIPEC showed that there were total 21 patients with recurrent GCT treated in seven different studies and 13 of 21 (61.9%) patients had no evidence of disease during follow\u2010up ranging from 6 to 100\u2009months. Three patients (14.2%) died of the disease. Six studies used cisplatin for HIPEC. At least 76.2% (16 of 21, data not available for five patients) had complete cytoreduction with total 16 cases of perioperative complications but no perioperative mortality was observed. Although further investigation is needed, we propose that CRS and HIPEC can be an effective therapeutic option for recurrent GCT at experienced institutions.<\/jats:p>","DOI":"10.1111\/jog.14494","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T03:59:41Z","timestamp":1603684781000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Management of recurrent granulosa cell tumor of the ovary: Contemporary literature review and a proposal of hyperthermic intraperitoneal chemotherapy as novel therapeutic option"],"prefix":"10.1111","volume":"47","author":[{"given":"Maya","family":"Yasukawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Gynecology Oncology, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"},{"name":"Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Division of Gynecology Oncology, Department of Obstetrics and Gynecology University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Dainty","sequence":"additional","affiliation":[{"name":"Regional Director of Gynecologic Oncology at Georgetown Lombardi Comprehensive Cancer Center, Chief of Gynecologic Oncology Department at MedStar Washington Cancer  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Sugarbaker","sequence":"additional","affiliation":[{"name":"Chief of Peritoneal Surface Malignancy Program and Director of the Center for Gastrointestinal Malignancies MedStar Washington Cancer Institute  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/pp-2016-0002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.03.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000037918.88451.6A"},{"key":"e_1_2_10_5_1","first-page":"1001","article-title":"A long\u2010term follow\u2010up study of 91 cases with ovarian granulosa cell tumors","volume":"34","author":"Shim SH","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2011.22.3.214"},{"key":"e_1_2_10_7_1","article-title":"Clinical determinants affecting indications for surgery and chemotherapy in recurrent ovarian granulosa cell tumor","volume":"7","author":"Nakai H","year":"2019","journal-title":"Healthcare (Basel)"},{"key":"e_1_2_10_8_1","unstructured":"Ovarian cancer including fallopian tube cancer and primary peritoneal cancer.2019. 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