{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:32:03Z","timestamp":1768699923105,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To present the feasibility, safety and outcomes of fetoscopic endoluminal tracheal occlusion (FETO) for the treatment of severe congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010arm clinical trial of FETO for isolated left\u2010sided CDH with liver herniation and Kitano Grade 3 stomach position (&gt;50% stomach herniation into the right chest). FETO was performed at 27\u201329\u2009weeks of gestation for cases with observed\/expected lung to head ratio (o\/e LHR) &lt;25% and at 30\u201331\u2009weeks for cases with o\/e LHR \u226525%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven cases were enrolled between March 2014 and March 2016, and balloon insertion was successful in all cases. The median o\/e LHR at entry was 27% (range, 20\u201333%). The median gestational age at FETO was 30.9 (range, 27.1\u201331.7) weeks. There were no severe maternal adverse events. One fetus died unexpectedly at 33\u2009weeks of gestation due to cord strangulation by the detached amniotic membrane. There were 3 cases (27%) of preterm premature rupture of membranes. In all 10 cases, balloon removal at 34\u201335\u2009weeks of gestation was successful. The median gestational age at delivery was 36.5 (range, 34.2\u201338.3) weeks. The median duration of occlusion and the median interval between balloon insertion and delivery were 26\u2009days (range: 17\u201349\u2009days) and 43\u2009days (range, 21\u201366\u2009days), respectively. Both the survival rate at 90\u2009days of age and the rate of survival to discharge were 45% (5\/11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The FETO is feasible without maternal morbidity in Japan and could be offered to women whose fetuses show severe isolated left\u2010sided CDH to accelerate fetal lung growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14504","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T05:29:16Z","timestamp":1601357356000},"page":"2598-2604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Feasibility and outcomes of fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: A Japanese experience"],"prefix":"10.1111","volume":"46","author":[{"given":"Seiji","family":"Wada","sequence":"first","affiliation":[{"name":"Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National 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