{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:29:41Z","timestamp":1792067381859,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare thermocoagulation and cryotherapy for treatment of high\u2010grade cervical intraepithelial neoplasia (CIN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2017 to May 2018, women with CIN2\/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow\u2010up at 4 and 8\u2009months included cytology and human papillomavirus (HPV) testing. Women who were HPV\u2010positive or had atypical squamous cells of undetermined significance or higher\u2010grade disease underwent colposcopy\/biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow\u2010up, there was no difference between the thermocoagulation and cryotherapy groups in HPV\u2010negative (4\/8\u2009months: 72.5%\/86.2% vs 68.6%\/80.6%) and pathology\u2010negative (97.1%\/98.5% vs 94.3%\/92.3%) rates (all <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The cytology\u2010negative rate was similar for thermocoagulation and cryotherapy at 4\u2009months (79.7% vs 78.9%, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), but higher for thermocoagulation at 8\u2009months (100% vs 88.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No lesions were observed among the four referral women at follow\u2010up. As compared with cryotherapy, thermocoagulation was associated with shorter duration of treatment and less vaginal discharge, but higher pain during application and longer bleeding after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high\u2010grade cervical lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14520","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T01:43:35Z","timestamp":1603331015000},"page":"279-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Thermocoagulation versus cryotherapy for the treatment of cervical precancers"],"prefix":"10.1111","volume":"47","author":[{"given":"Lyufang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome L.","family":"Belinson","sequence":"additional","affiliation":[{"name":"Preventive Oncology International  Cleveland Heights Ohio USA"},{"name":"Women's Health Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfeng","family":"Qu","sequence":"additional","affiliation":[{"name":"Sanming Project of Medicine in Shenzhen Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Key Laboratory on Technology for Early Diagnosis of 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