{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T17:54:34Z","timestamp":1723485274134},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the effect of piroxicam adjuvant therapy on the clinical and biochemical pregnancy rate in patients undergoing in vitro fertilization (IVF) and frozen\u2013thawed embryo transfer (ET) cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized, double\u2010blinded, placebo\u2010controlled clinical trial, 178 patients eligible for IVF\u2010ET received either single dose of piroxicam 1\u20132\u2009h before frozen\u2013thawed ET or a placebo at the same time. Study participants were then followed and compared regarding the primary outcome of the study, which was biochemical (positive \u03b2\u2010human chorionic gonadotrophin test) and clinical pregnancy (detected fetal heart beat in ultrasound) rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of this study indicated that there is no significant association between the piroxicam administration before frozen\u2013thawed ET and the clinical or biochemical pregnancy rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.208 and <jats:italic>P<\/jats:italic> =\u20090.699, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of the current study suggest that piroxicam administration before ET has no beneficial effects on pregnancy rate among women undergoing IVF and frozen\u2013thawed ET. However, further studies with larger sample sizes and longer follow\u2010ups are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14521","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T01:46:09Z","timestamp":1602207969000},"page":"296-301","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of piroxicam administration on outcome of frozen\u2013thawed embryo transfer: A randomized, double\u2010blinded, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"47","author":[{"given":"Afsoon","family":"Zarei","sequence":"first","affiliation":[{"name":"Infertility Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahid","family":"Homayoon","sequence":"additional","affiliation":[{"name":"Infertility Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department 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