{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:36:45Z","timestamp":1791459405780,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical outcome of assisted reproductive technology (ART) cycles in couple with male infertility, where the spermatozoa were selected using either a conventional gradient\u2010density centrifugation technique or microfluidic sperm sorting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 181 patients who underwent in vitro fertilization (IVF) because of male factor infertility at the IVF center of Bezmialem and Yeditepe University Hospital were included in this study. All patients were divided into two groups according to the sperm selection method: group I (<jats:italic>n<\/jats:italic> = 91): microfluidic sperm\u2010sorting chip; group II (<jats:italic>n<\/jats:italic> = 90): density\u2010gradient centrifugation. Data collected included male and female age, type of infertility, duration of infertility, previous IVF attempts, smoking, antral follicle count, total dosage of gonadotropins, maximum estradiol levels, duration of stimulations, endometrial thickness on human chorionic gonadotropin day, total number of oocytes retrieved, number of mature oocytes retrieved, number of pronuclear (PN), sperm parameters, clinical PR and ongoing PR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference in clinical PR and ongoing PR between groups (49.5% vs 40%, <jats:italic>P<\/jats:italic> = 0.2; 44% vs 36.7%, <jats:italic>P<\/jats:italic> = 0.3; respectively). The improvement in pregnancy rate was more prominent in patients where the female partner's age is higher than 35 (<jats:italic>P<\/jats:italic> = 0.09) and men have a total motile sperm count between 1 and 5 million (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microfluidic devices, \u201clabs\u2010on\u2010a\u2010chip,\u201d are a disposable, easy to use, and inexpensive method for sperm sorting. Our results show that IVF success rates might improve with the use of a microfluidic sperm\u2010sorting chip for sperm selection in male infertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14539","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:33:12Z","timestamp":1605573192000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Does the use of microfluidic sperm sorting for the sperm selection improve in vitro fertilization success rates in male factor infertility?"],"prefix":"10.1111","volume":"47","author":[{"given":"Pinar","family":"Ozcan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Bezmialem University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Takmaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bezmialem University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis G\u00f6kce Kocer","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yeditepe University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya Akcin","family":"Alagoz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yeditepe University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Yesiladali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yeditepe University Faculty of Medicine  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Sevket","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 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