{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:12:30Z","timestamp":1784542350577,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701402"],"award-info":[{"award-number":["81701402"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical efficacy and safety of laparoscopic adenomyomectomy combined with intraoperative replacement of levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) in the treatment of symptomatic adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2010series study in a university medical center. A total of 52 patients with symptomatic adenomyosis were treated by laparoscopic adenomyomectomy combined with intraoperative replacement of LNG\u2010IUS from January 2015 to July 2018. Visual analog scale, menstrual flow and uterine volume were compared before and after the surgery (3, 12 and 24\u2009months). Meanwhile, LNG\u2010IUS\u2010induced adverse reactions (e.g. irregular vaginal bleeding, amenorrhea, expulsion, and perforation) were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All operations were successfully completed via laparoscopy without conversion to laparotomy. No severe complications were noted during the surgical procedure or follow\u2010up period. The mean postoperative visual analog scale and menstrual flow scores and the volume of the uterus were significantly decreased (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at 3, 12, and 24\u2009months postoperatively, compared with preoperative scores. The clinical effective rates among the patients with dysmenorrhea were 98%, 96% and 96% at 3, 12 and 24\u2009months after the operation, respectively. And the clinical effectiveness rate of menorrhagia was 97.6%, 95.2% and 95.2% at 3, 12 and 24\u2009months after treatment, respectively. Among all related adverse reactions, amenorrhea was the most common (<jats:italic>n<\/jats:italic> = 12, 23.1%). There was one case of LNG\u2010IUS perforation (1.9%) and two cases of expulsion (3.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laparoscopic adenomyomectomy combined with intraoperative replacement of LNG\u2010IUS is a novel and effective conservative surgical procedure for symptomatic adenomyosis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14571","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T02:32:49Z","timestamp":1605061969000},"page":"613-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Laparoscopic adenomyomectomy combined with l<scp>evonorgestrel\u2010releasing<\/scp> intrauterine system in the treatment of adenomyosis: Feasibility and effectiveness"],"prefix":"10.1111","volume":"47","author":[{"given":"Feng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"You","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YePing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YingYing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Shanghai Key Laboratory of Embryo Original Diseases  Shanghai China"},{"name":"Shanghai Municipal Key Clinical Specialty  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000346"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.10.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2841-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.05.091"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2011.43"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.07.014"},{"key":"e_1_2_7_8_1","first-page":"45","article-title":"Safety, efficacy and patient acceptability of the contraceptive and non\u2010contraceptive uses of the LNG\u2010IUS","volume":"1","author":"Bednarek PH","year":"2010","journal-title":"Int J Womens Health"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.10.798"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh650"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.05.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.11.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2004.07.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5301\/JE.2012.9725"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)12355-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-015-0182-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2015.05.024"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441783"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2518396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms006"},{"key":"e_1_2_7_21_1","first-page":"3430","article-title":"Recurrence\u2010associated factors of laparoscopic adenomyomectomy for severely symptomatic adenomyoma","volume":"16","author":"Yu W","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.1744"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S205561"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351431"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4105-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2008.11.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex088"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-4018-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014579"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14673"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T15:39:42Z","timestamp":1693755582000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/jog.14571"],"URL":"https:\/\/doi.org\/10.1111\/jog.14571","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"2020-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}