{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:27Z","timestamp":1787015667982,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the value of uterine CD138+ cells, as a marker of chronic endometritis, in predicting subsequent reproductive outcome in women with history of recurrent pregnancy loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective longitudinal study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary specialized clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Women with history of recurrent pregnancy loss or implantation failure over a 12\u2010months follow\u2010up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>We quantified the CD138+ cells\/high powered field (hpf) using immunohistochemistry and image analysis of endometrial biopsies obtained during the secretory stage post ovulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>Live birth and subsequent pregnancy loss. We calculated the receiver operator curve for predicting subsequent pregnancy loss and reported using relative risk (RR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 344 women of whom 88 became pregnant (88\/344, 25.5%). Half of them had a subsequent live birth (47\/88, 53%) and the rest lost their pregnancy (41\/88, 46%). The median CD138+ score was significantly lower in the live birth group (\n                      <jats:styled-content>\n                        <jats:italic>P<\/jats:italic>\n                      <\/jats:styled-content>\n                      &lt;\u20090.005) and women with a CD138+ score\u2009\u2265\u200916\/hpf had a higher risk of subsequent miscarriage (RR 10.0, 95% CI 2.78\u201336.02). CD138+ cells count showed a good prediction for subsequent pregnancy loss in high\u2010risk women with an area under the curve of 0.75 (95% CI 0.59\u20130.82,\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.01). A cut\u2010off value of 4\u20136 cells\/hpf offered the best predictive accuracy with higher scores predicting worse reproductive outcome. Our findings are limited by the small event rate and the sample size of our cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quantifying CD138+ cells by immunohistochemistry in women with a history of recurrent pregnancy loss is helpful to diagnose chronic endometritis and predict subsequent reproductive outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.14585","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:15:29Z","timestamp":1607040929000},"page":"689-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Quantifying\n                    <scp>CD138<\/scp>\n                    + cells in the endometrium to assess chronic endometritis in women at risk of recurrent pregnancy loss: A prospective cohort study and rapid review"],"prefix":"10.1111","volume":"47","author":[{"given":"Michael P.","family":"Rimmer","sequence":"first","affiliation":[{"name":"MRC Centre for Reproductive Health, Queens Medical Research Institute, Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Fishwick","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Henderson","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"},{"name":"University Hospital Coventry and Warwickshire NHS Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chinn","sequence":"additional","affiliation":[{"name":"Research and Development Office, NHS Fife, Queen Margaret Hospital, Whitefield Road, Dunfermline  Fife UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassel H.","family":"Al Wattar","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"},{"name":"University Hospital Coventry and Warwickshire NHS Trust  UK"},{"name":"Women's Health Research Unit, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Quenby","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick  Coventry UK"},{"name":"University Hospital Coventry and Warwickshire NHS Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072075"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01051.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.07.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1000-RSIAIT"},{"key":"e_1_2_7_6_1","first-page":"69","article-title":"Evaluation of endometrium for chronic endometritis by using Syndecan\u20101 in abnormal uterine bleeding","volume":"4","author":"Kannar V","year":"2012","journal-title":"J Laboratory Phys"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5653\/cerm.2016.43.4.185"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12782"},{"key":"e_1_2_7_9_1","first-page":"954","article-title":"Endometrial biopsy in the infertility investigation. 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