{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:50:13Z","timestamp":1776826213783,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Dienogest (DNG) is highly effective for relieving pain caused by endometriosis and adenomyosis. However, women with severe uterine swelling due to adenomyosis who take DNG usually experience metrorrhagia. This study aimed to examine the safety of DNG usage in women with adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 20 women who were prescribed DNG for adenomyosis in our hospital from January 2016 to December 2016. We retrospectively analyzed women's clinical background characteristics (age, the use of the gonadotropin\u2010releasing hormone agonist as pre\u2010treatment of DNG, the uterus size [major axis, minor axis, maximum thickness in the myometrium, and length of the uterine body] by transvaginal ultrasonography [TVUS], hemoglobin level, and the presence of metrorrhagia during treatment). These variables were compared between the DNG continuation and discontinuation groups using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen women continued DNG, and seven discontinued DNG within 12\u2009months because of metrorrhagia. The uterine size was significantly larger in the discontinuation group than in the continuation group. All uterine measurements had high Spearman rank correlation coefficients (\u03c1\u2009&gt;\u20090.8, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In six of seven cases in the discontinuation group, adenomyosis was in the anterior wall. Measuring the uterus size and locating adenomyosis by TVUS are simple methods of predicting DNG discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We consider that DNG can be safely administered in women with adenomyosis if the uterine size is &lt;6\u2009cm in the minor axis and the main lesion of adenomyosis is located in the posterior uterine wall.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14612","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T08:06:47Z","timestamp":1613549207000},"page":"1433-1440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluating the safety of dienogest in women with adenomyosis: A retrospective analysis"],"prefix":"10.1111","volume":"47","author":[{"given":"Natsumi","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Molecular Reproductive Science Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"163","article-title":"Adenomyosis: Prevalence, risk factors, symptoms and clinical findings","volume":"34","author":"Yeniel O","year":"2007","journal-title":"Clin Exp Obstet 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