{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:46:56Z","timestamp":1781819216959,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To elucidate correlation between signal intensity on diffusion\u2010weighted images (SI\u2010DWI) and clinical backgrounds for uterine adenomyosis and to compare SI\u2010DWI of adenomyosis and malignant uterine tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study examined 46 adenomyosis patients diagnosed using magnetic resonance imaging and 25 patients with surgically confirmed malignant uterine myometrial tumor. First, adenomyosis cases were classified visually into high\u2010intensity and low\u2010intensity groups based on the SI\u2010DWI compared with that of normal uterine myometrium. Secondly, correlation was assessed between SI\u2010DWI of adenomyosis and patient clinical background information such as age, menopausal status, menstrual cycle and dysmenorrhea severity. Third, quantitative comparison was made of low\u2010intensity adenomyosis (LIA), high\u2010intensity adenomyosis (HIA) and malignant tumor groups for the signal intensity ratio (SIR) on DWI and the apparent diffusion coefficient (ADC). Their diagnostic performance was evaluated using logistic regression analysis and receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 46 adenomyosis cases were classified as 26 low\u2010intensity and 20 high\u2010intensity cases. Significant correlation was found only for menstrual cycle phases. HIA had significantly lower SIR and higher ADC than malignant tumor. The ADC of HIA was significantly higher than that of LIA. The combination of SIR and ADC showed excellent diagnostic performance (area under ROC curve, 0.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a variation in signal intensity on DWI of uterine adenomyosis and it is associated with menstrual cycle phase. Adenomyosis with high signal intensity on DWI can be differentiated from malignant lesions by its lower signal intensity on DWI and higher ADC than that found for malignant uterine tumors, however overlaps exist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14621","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T07:42:01Z","timestamp":1611906121000},"page":"949-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diffusion\u2010weighted imaging of uterine adenomyosis: Correlation with clinical backgrounds and comparison with malignant uterine tumors"],"prefix":"10.1111","volume":"47","author":[{"given":"Ryo","family":"Yajima","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of Medicine  Kyoto 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