{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:54:18Z","timestamp":1786719258899,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of ultra\u2010long protocol on reproductive and controlled ovarian hyperstimulation outcome in in vitro fertilization\/intracytoplasmic sperm injection\u2010embryo transfer (IVF\/ICSI\u2010ET) in infertile women with endometriosis versus long protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved articles without language restrictions in the Elsevier ScienceDirect, Embase, Medline, PubMed, Web of Science, China National Knowledge Infrastructure, Wan Fang Data Knowledge Service Platform and China Science and Technology Journal Database from inception to August 2020. RCTs including the comparison of reproductive outcome of infertile patients with endometriosis who underwent ultra\u2010long protocol and long protocol were selected. Data extraction was conducted using RevMan 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of nine RCTs in compliance with the standard literature were included. This meta\u2010analysis suggested that ultra\u2010long protocol with a 3\u2010month downregulation could increase clinical pregnancy rate of infertile women with endometriosis (RR=1.31, 95% CI:1.11 ~\u20091.55, <jats:italic>P<\/jats:italic> =\u20090.002) versus long protocol. However, subgroup analysis found the different protocol provided no significant difference in improving clinical outcomes in patients with different disease stage of endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ultra\u2010long protocol could improve the clinical pregnancy rate of infertile women with endometriosis compared with long protocol with a 3\u2010month downregulation. And ultra\u2010long protocol could be effective to increase the ongoing pregnancy rate compared to long\u2010protocol. But, the efficacy of ultra\u2010long protocol is not different between early and advanced stage of endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14630","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:35:53Z","timestamp":1610692553000},"page":"1232-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effectiveness of ultra\u2010long protocol on in vitro fertilization\/intracytoplasmic sperm injection\u2010embryo transfer outcome in infertile women with endometriosis: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"47","author":[{"given":"Shuai","family":"Liu","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0008-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.06.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61439-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60490-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.08.068"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03112-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4401(05)80013-0"},{"key":"e_1_2_7_10_1","first-page":"Cd004635","article-title":"Long\u2010term pituitary down\u2010regulation before in vitro fertilization (IVF) for women with endometriosis","volume":"25","author":"Sallam HN","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_11_1","first-page":"CD013240","article-title":"Long\u2010term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis","volume":"2019","author":"Georgiou EX","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew148"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-020-00571-6"},{"key":"e_1_2_7_15_1","first-page":"339","article-title":"The PRISMA statement for reporting systematic reviews and meta\u2010analyses of studies that evaluate healthcare interventions: Explanation and elaboration","volume":"2700","author":"Liberati A","year":"2009","journal-title":"BMJ"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"e_1_2_7_17_1","first-page":"343","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"5928","author":"Higgins JP","year":"2011","journal-title":"BMJ"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03338-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03373-3"},{"key":"e_1_2_7_20_1","first-page":"51","article-title":"Effect of gonadotropin\u2010releasing hormone agonist on the outcomes of in vitro fertilization\u2010embryo transfer in patients with severe endometriosis","volume":"39","author":"Lin Wq LJ","year":"2004","journal-title":"Chin J Obstet Gynecol"},{"key":"e_1_2_7_21_1","first-page":"4992","article-title":"Comparison of the effects of two regimens on IVF\u2010ET in patients with severe endometriosis","volume":"24","author":"Mo Fm QY","year":"2011","journal-title":"Med Inf"},{"key":"e_1_2_7_22_1","first-page":"202","article-title":"Different GnRH\u2010a down\u2010regulation protocols for in vitro fertilization\u2010embryo transfer in infertility patients with endometriosis","volume":"6","author":"Dai LCL","year":"2017","journal-title":"Clin Lab Sci (Electronic Edition)"},{"key":"e_1_2_7_23_1","first-page":"1","article-title":"Research on different GnRH\u2010down\u2010regulation protocols for in vitro fertilization and embryo transfer in infertile women with endometriosis","volume":"2","author":"Hl J","year":"2018","journal-title":"Mod Med Health Res"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118756753"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.018"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916447"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.09.027"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.031"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-017-0341-4"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00769-6"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.12.002"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511734755.004"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:16:36Z","timestamp":1693631796000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jog.14630"],"URL":"https:\/\/doi.org\/10.1111\/jog.14630","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2020-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}