{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:04:28Z","timestamp":1759565068056},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to examine whether serum levels of placental growth factor (PlGF) and soluble endoglin (sEng) at 19\u201325 and 26\u201331\u2009weeks of gestation were associated with the occurrence of the 9\u2010block categorization of placenta weight (PW) and fetal\/placenta ratio (F\/P ratio).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study in 1391 women with singleton pregnancy. Serum levels of PlGF and sEng were measured by enzyme immunosorbent assay. A light placenta was defined as PW ZS\u2009&lt;\u2009\u22121.28 SD. Based on the PW (light, normal, and heavy) and F\/P ratio (relatively heavy, balanced growth, and relatively small), 9\u2010block categorization were performed. Multivariable logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low PlGF at 26\u201331\u2009weeks was an independent risk factor for the birth of infants belonging to Block A (light placenta and relatively heavy infant), after adjusting for prepregnancy body mass index and serum levels of sEng. High sEng at 26\u201331\u2009weeks was an independent risk factor for the birth of infants belonging to Block D (light placenta and balanced growth of infant), after adjusting for past history of either preeclampsia or gestational hypertension, high pulsatility index of uterine artery flow velocity waveforms in the second trimester, and serum level of PlGF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low PlGF levels at 26\u201331\u2009weeks of gestation may precede a light placenta and relatively heavy infant (Block A), and high sEng levels at 26\u201331\u2009weeks of gestation may precede a light placenta and balanced growth of infant (Block D).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14636","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T22:13:30Z","timestamp":1609971210000},"page":"1040-1051","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low placental growth factor levels and high soluble endoglin levels at 26\u201331\u2009weeks of gestation precede light placenta with and without relatively heavy infant, respectively: A retrospective cohort study"],"prefix":"10.1111","volume":"47","author":[{"given":"Chikako","family":"Hirashima","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihide","family":"Ohkuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemal","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Food and Health Sciences Jissen Women's University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotada","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi 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