{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:39:37Z","timestamp":1790811577945,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Laparoscopic surgery is widely used for diagnosing ovarian endometriosis but it has medical risks. This study explored the application of blood indicators in diagnosis and staging of ovarian endometriosis, aiming to develop a noninvasive diagnostic method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 190 ovarian endometriosis patients were included in observation group, among these participants, 77 patients among them were stages I\u2013II, and the rest 113 patients were stages III\u2013IV, and a total of 103 healthy women as control group. Serum biochemical indexes, tumor markers, and cytokines levels in two groups were used for the diagnosis and staging of the disease. Area under the receiver operating characteristic (ROC) curve (AUC) predicted the value of individual and joint tests for indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biochemical indexes, namely, alkaline phosphatase (ALP), total protein (TP), and glucose (Glu) could distinguish patients from normal women; and that ALP and Glu could indicate disease staging. In tumor markers, alpha fetoprotein (AFP), carcinoembryonic antigen (CA) 125, CA199 and human epididymis protein 4 (HE4) helped to diagnose endometriosis; CA125, HE4, and cytokeratin 19 fragment (CYFRA21\u20101) could differentiate stages. In cytokines, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20106, soluble fms\u2010like tyrosine kinase receptor 1 (sflt\u20101), monocyte chemoattractant protein (MCP)\u20101 therefore, have values to diagnose endometriosis; VEGF, TNF\u2010\u03b1, IL\u20106, and sflt\u20101 helped to differentiate disease staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serological indicators in ovarian endometriosis patients were different from healthy women, which were of certain differential values in diagnosis and disease staging. The current study provided a novel strategy for endometriosis diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14654","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:00:35Z","timestamp":1610751635000},"page":"1441-1450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Application of serum markers in diagnosis and staging of ovarian endometriosis"],"prefix":"10.1111","volume":"47","author":[{"given":"Ting","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gynaecology Ganzhou People's Hospital of Jiangxi Province  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Ganzhou People's Hospital of Jiangxi Province  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Ganzhou People's Hospital of Jiangxi Province  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Ganzhou People's Hospital of Jiangxi Province  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction Ganzhou People's Hospital of Jiangxi Province  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13372"},{"issue":"5","key":"e_1_2_6_3_1","article-title":"An eight\u2010year retrospective analysis of laparoscopic surgery for endometriosis, outcomes and complications in a large multicenter unit","volume":"46","author":"Ratner RHA","year":"2019","journal-title":"Clin Exp Obstetr Gynecol."},{"issue":"3","key":"e_1_2_6_4_1","first-page":"349","article-title":"Endometriosis still a challenge","volume":"7","author":"Mehedintu C","year":"2014","journal-title":"J Med Life"},{"issue":"1","key":"e_1_2_6_5_1","first-page":"43","article-title":"Is the oocyte quality affected by endometriosis? 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