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Endometriosis generates a unique microenvironment for survivability of endometriotic lesions which includes cell proliferation, differentiation, migration, and apoptosis. For these cellular activities, cascading activations of intracellular kinases are needed. Many kinase signaling pathways, IKK\u03b2\/NK\u2010\u03baB pathway, PI3K\/AKT\/mTOR, and the mitogen\u2010activated protein kinase (MAPK) pathways (ERK1\/2, p38, and JNK), are activated in endometriosis. In this review, we focus on the role of MAPK pathways in endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify the role of MAP Kinase signaling pathway in endometriosis we searched the Pubmed database using the search terms in various combinations \u201cendometriosis,\u201d \u201cendometrium,\u201d \u201covary,\u201d \u201cMAPK pathway,\u201d \u201cERK pathway,\u201d \u201cp38 pathway,\u201d \u201cJNK pathway,\u201d \u201cestrogen,\u201d and \u201cprogesterone.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>According to the current literature, MAPK signaling pathway has various roles in generating microenvironment and survival of endometriosis. Abnormal MAPK activation in migration, implantation, growth, invasion into the pelvic structures, proliferation, and apoptosis leads to the form of endometriosis and to worsen the condition in patients with endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To further investigations on the effective and long\u2010term endometriosis treatment, MAPK signaling pathways may be targeted. Molecular mechanism of MAPK signaling pathway in endometriosis should be more deeply understood and clinical trials should be more commonly performed for possible new endometriosis treatments to improve fertility and rescue endometriosis irreversibly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.14710","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T11:14:52Z","timestamp":1613646892000},"page":"1610-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["The role of mitogen\u2010activated protein kinase signaling pathway in endometriosis"],"prefix":"10.1111","volume":"47","author":[{"given":"Gizem","family":"Bora","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Yeditepe University School of Medicine  \u0130stanbul 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