{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:36:15Z","timestamp":1776875775121,"version":"3.51.2"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018GXNSFBA138047"],"award-info":[{"award-number":["2018GXNSFBA138047"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the regulatory role and molecular mechanism of lncRNA\u2010LINC01279 in endometriosis (EMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between September 2018 and July 2019, 20 EMs patients and 20 healthy subjects were recruited to detect the expression of lncRNA\u2010LINC01279 in EMs and in normal endometrium via qRT\u2010PCR. Autograft was used to establish EMs models on Spraque\u2013Dawley (SD) rats, which was followed by taking volume measurements of EMs endometrium and observing pathological changes in the morphology of EMs via hematoxylin and eosin (H&amp;E) staining. The qRT\u2010PCR technique was further carried out to determine mRNA expression of lncRNA\u2010LINC01279 and <jats:italic>HOXA10<\/jats:italic> in the serum of EMs rats and LINC01279 shRNA\u2010transfected rats, while the protein expression of <jats:italic>HOXA10<\/jats:italic> was determined using a Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EMs patients presented with upregulation of lncRNA\u2010LINC01279 and downregulation of <jats:italic>HOXA10<\/jats:italic> (<jats:italic>p\u2009&lt;<\/jats:italic> 0.01 or 0.001). Online predictions further revealed that lncRNA\u2010LINC01279 regulated the expression of <jats:italic>HOXA10<\/jats:italic> via miRNA\u2010135b. In EMs models, it was observed that there were a significantly enlarged endometrium and poor pathological morphology, significant upregulation of lncRNA\u2010LINC01279, and downregulation of miR\u2010135b and <jats:italic>HOXA10<\/jats:italic> in serum (<jats:italic>p\u2009&lt;<\/jats:italic> 0.05, 0.01 or 0.001). In the lncRNA\u2010LINC01279 shRNA group, EMs rats, following treatment, had a sharp decrease in the volume of EMs endometrium, and an improvement in pathological morphology, while lncRNA\u2010LINC01279 was downregulated, with upregulation of miR\u2010135b and <jats:italic>HOXA10<\/jats:italic> (<jats:italic>p\u2009&lt;<\/jats:italic> 0.05, 0.01 or 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LncRNA\u2010LINC01279, by the mechanism of targeting miR\u2010135b, has the potential to downregulate the expression of <jats:italic>HOXA10<\/jats:italic>, and therefore, can promote the development and progression of EMs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14723","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T23:44:22Z","timestamp":1614815062000},"page":"1825-1836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>Lnc\u2010RNA LINC01279<\/scp> induces endometriosis via targeting of <scp><i>HOXA10<\/i><\/scp>"],"prefix":"10.1111","volume":"47","author":[{"given":"Liling","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Center The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Center The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Center The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The First Affiliated Hospital of GuangXi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifu","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The First Affiliated Hospital of GuangXi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The First Affiliated Hospital of GuangXi Medical University  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-396X","authenticated-orcid":false,"given":"Weihong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Center The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02486-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijn.12833"},{"key":"e_1_2_7_4_1","first-page":"1079","article-title":"Epidemiological aspects of the outcomes from the treatment of endometriosis: experience from two different geographical areas","volume":"19","author":"Matalliotaki C","year":"2020","journal-title":"Exp Ther Med"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719119831775"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61702-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","DOI":"10.23736\/S0031-0808.20.03866-5","article-title":"The differential ultrasonic diagnosis of ovarian endometriosis and ovarian cancer","author":"Deng H","year":"2020","journal-title":"Panminerva Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00935"},{"key":"e_1_2_7_9_1","first-page":"3610","article-title":"FOXP1 enhances fibrosis via activating Wnt\/beta\u2010catenin signaling pathway in endometriosis","volume":"10","author":"Shao X","year":"2018","journal-title":"Am J Transl Res"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5455\/aim.2018.26.254-257"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2019.100067"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.09.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117734320"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3836-1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.6.1338"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9471-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1597"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-11-0438"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.11.027"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1231"},{"key":"e_1_2_7_21_1","first-page":"3850","article-title":"Identification of LINC01279 as a cell cycleassociated long noncoding RNA in endometriosis with GBA analysis","volume":"18","author":"Liu J","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505245"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaz040"},{"key":"e_1_2_7_24_1","first-page":"1","article-title":"Long noncoding RNA NORAD regulates lung cancer cell proliferation, apoptosis, migration, and invasion by the miR\u201030a\u20105p\/ADAM19 axis","volume":"13","author":"Li J","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_25_1","first-page":"1278","article-title":"Long noncoding RNA NORAD promotes the progression of retinoblastoma by sponging miR\u2010136\u20105p\/PBX3 axis","volume":"24","author":"Yang XL","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2019.12.013"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.01.024"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2019.8008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.11.010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/41149"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky905"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23364"},{"key":"e_1_2_7_33_1","first-page":"7","article-title":"Endometriosis: a new approach to etiology and pathogenesis (review)","volume":"273","author":"Solopova A","year":"2017","journal-title":"Georgian Med News"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:34:25Z","timestamp":1693593265000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/jog.14723"],"URL":"https:\/\/doi.org\/10.1111\/jog.14723","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}