{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:32Z","timestamp":1747186532276,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hyperinsulinemia is a known underlying driver of metabolic disease; however, its role in pregnancy complications is less understood due to insulin measurement not being a part of standard clinical assessments. This study aimed to characterize hyperinsulinemia in pregnancy by gestational diabetes (GD) status using Kraft methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed historical data from 926 pregnant women who underwent a 100\u2010g oral glucose tolerance test (OGTT), which included insulin measurement. Subjects were grouped by GD diagnosis status (\u201cNormal\u201d, \u201cBorderline\u201d, \u201cGD\u201d) and insulin responses over 3\u2009h were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u201cGD\u201d was diagnosed in 20.3% of the subjects and 13.8% were grouped as \u201cBorderline.\u201d The prevalence of hyperinsulinemia using the Kraft algorithm was 33.1% for Kraft IIB and 42.0% for Kraft III. Compared to normal glucose\u2010tolerant mothers, individuals from the \u201cBorderline\u201d group had an exacerbated insulin response, although not to the same magnitude as those with \u201cGD.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dynamic OGTT insulin measurement during pregnancy may provide a meaningful assessment of metabolic risk among women who would otherwise not be diagnosed with GD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14731","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:33:06Z","timestamp":1614904386000},"page":"1719-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperinsulinemia during pregnancy across varying degrees of glucose tolerance: An examination of the Kraft database"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-8665","authenticated-orcid":false,"given":"Sylvia","family":"North","sequence":"first","affiliation":[{"name":"Human Potential Centre, Faculty of Health and Environmental Sciences Auckland University of Technology  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caryn","family":"Zinn","sequence":"additional","affiliation":[{"name":"Human Potential Centre, Faculty of Health and Environmental Sciences Auckland University of Technology  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-8513","authenticated-orcid":false,"given":"Catherine","family":"Crofts","sequence":"additional","affiliation":[{"name":"Human Potential Centre, Faculty of Health and Environmental Sciences Auckland University of Technology  Auckland New Zealand"},{"name":"School of Public Health and Interdisciplinary 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