{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:08:00Z","timestamp":1774084080585,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Next\u2010generation sequencing (NGS) is able to describe the composition of human papillomaviruses (HPVs) as percent (%) reads rather than positive\/negative results. Therefore, we used this unique approach to assess the prevalence of cervical HPVs of HIV infected (HIV+) in order to understand the determinants of being infected with higher % reads of high risk (HR)\u2010HPVs and cervical abnormalities of atypical squamous cells of unknown significance or higher (ASCUS+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study included 66 women characterized for relevant risk factors\/cytology. Receiver\u2010operating curve curve was used to derive the optimal % read cut point to identify ASCUS+ in relation to any HR\u2010HPV genotype or other specific HPV genotypes. The determinants of ASCUS+ and HR\u2010HPVs were tested using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with &gt;20% reads of any HR\u2010HPV or &gt;12% any HR\u2010HPV other than HPV 16\/18 were 5.7 and 12.6 times more likely to be diagnosed with ASCUS+, respectively. Lower CD4 count was a significant determinant of &gt;20% reads of HR\u2010HPV (odds ratio [OR]\u00a0=\u00a04.1) or &gt;12% any HR\u2010HPV other than HPV 16\/18 (OR\u00a0=\u00a04.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We envision that the NGS\u2010based HPV detection will be more accurate for screening and management of HIV+ at risk for developing cervical cancer (CC). We raise concerns regarding the limitations of 16\/18\u2010based HPV testing for triage and the efficacy of current HPV vaccines for preventing CC in HIV+.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14754","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:56:52Z","timestamp":1616486212000},"page":"2185-2195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human papillomavirus sequencing reveals its usefulness for the management of <scp>HIV<\/scp>\u2010infected women at risk for developing cervical cancer"],"prefix":"10.1111","volume":"47","author":[{"given":"Chandrika J.","family":"Piyathilake","sequence":"first","affiliation":[{"name":"Department of Nutrition Sciences The University of Alabama at Birmingham (UAB)  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit","family":"Kumar","sequence":"additional","affiliation":[{"name":"UAB Center for Clinical &amp; Translational Science The University of Alabama at Birmingham (UAB)  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Genetics The University of Alabama at Birmingham (UAB)  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguna","family":"Badiga","sequence":"additional","affiliation":[{"name":"Department of Nutrition Sciences The University of Alabama at Birmingham (UAB)  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greer A.","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases The University of Alabama at Birmingham (UAB)  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081355"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.226"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-6-11"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000222716.17186.9f"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.12.060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09028-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200304150-00010"},{"key":"e_1_2_9_9_1","volume-title":"UNAIDS 2016\u20132021 Strategy","author":"UNAIDS","year":"2015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.06.041"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.10.058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/505876"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.086"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038731"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/SO100-720320140004995"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32315"},{"issue":"3","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1067\/mob.2001.109938","article-title":"The role of human papillomavirus deoxyribonucleic acid assay and repeated cervical cytologic examination in the detection of cervical intraepithelial neoplasia among human immunodeficiency virus\u2010infected women. 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