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During pregnancy, the elevated demand for micronutrients put pregnant women at even higher risk of micronutrients deficiency. Some micronutrients are relatively famous such that women with reproductive age are recommended to take folic acid supplementation for the prevention of neural tube defect. However, it is not generally known that folate is also important for fetal growth throughout the pregnancy course and for prevention of pregnancy complications, and that pregnant women should continue to take supplementation during pregnancy and lactation. The types of micronutrients and the duration of supplementation are both important factors to maintain normal pregnancies. This review focused on four micronutrients that are commonly deficient in Japanese pregnant women, folate, vitamin B12, vitamin D, calcium, and magnesium. The detrimental effects of homocysteine accumulation associated with the above micronutrient defects and its link to catechol\u2010o\u2010methyltransferase insufficiency are described. We also discussed possible molecular mechanisms of pregnancy complications and the development origin of health and disease (DOHaD) regarding micronutrient deficiencies from the point of view of one carbon metabolism.<\/jats:p>","DOI":"10.1111\/jog.14770","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T01:53:45Z","timestamp":1617069225000},"page":"1965-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The impact of micronutrient deficiency on pregnancy complications and development origin of health and disease"],"prefix":"10.1111","volume":"47","author":[{"given":"Keizo","family":"Kanasaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Shimane University Faculty of Medicine  Izumo Shimane Japan"},{"name":"Division of Anticipatory Molecular Food Science and Technology Medical Research Institute, Kanazawa Medical University  Uchinada Ishikawa 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