{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:30:08Z","timestamp":1793298608393,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether three\u2010dimensional (3D) placental vascular indices and volumes during the first trimester of pregnancy can be used as predictors of subsequent adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective cohort study including women with singleton pregnancies between 10 and 13\u2009weeks. 3D placental volume and vascular indices and uterine artery pulsatility index (UtA\u2010PI) were measured. Adverse outcomes were defined whether there was any of the following complications: small for gestational age pregnancy, preterm delivery, and preeclampsia. The serum pregnancy\u2010associated plasma protein\u2010A (PAPP\u2010A) and free beta\u2010human chorionic gonadotropin (\u03b2\u2010hCG) levels were also compared. We analyzed the screening performances of these parameters for prediction of any of adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 348 women screened, 300 women were completed follow\u2010up. Overall, 57 (19.0%) of 300 women developed any of adverse pregnancy outcomes.<\/jats:p><jats:p>Multiple logistic regression analysis demonstrated that gestational age\u2014adjusted <jats:italic>z<\/jats:italic>\u2010scores of log<jats:sub>10<\/jats:sub> placental volume (odds ratio [OR], 0.572; 95% confidence interval [CI], 0.416\u20130.788), log<jats:sub>10<\/jats:sub> placental vascularization flow index (VFI; OR, 0.676; 95% CI, 0.496\u20130.921), and log<jats:sub>10<\/jats:sub> UtA\u2010PI (OR, 1.910; 95% CI, 1.335\u20132.731) were significantly associated adverse pregnancy outcomes. The multivariate model combining placental VFI, placental volume, UtA\u2010PI, and underweight or obese body mass index exhibited the highest screening performances (AUC\u00a0=\u00a00.77) and PAPP\u2010A and \u03b2\u2010hCG did not add any significance to multivariate model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Placental volume and vascular indices at 10\u201313\u2009weeks of gestation are significantly associated with adverse pregnancy outcomes. Combination of these placental indices and UtA\u2010PI could improve the screening performance for adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14781","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:47:30Z","timestamp":1617670050000},"page":"2051-2058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combination of three\u2010dimensional placental vascular indices and volume and uterine artery pulsatility index at 10\u201313\u2009weeks of gestation could improve the prediction of adverse pregnancy outcomes"],"prefix":"10.1111","volume":"47","author":[{"given":"In Yang","family":"Park","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong ha","family":"Wie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Catholic University of Korea  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Catholic University of Korea  Seoul South 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