{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:26:12Z","timestamp":1769829972595,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Androgens have been reported to be associated with female fertility. The mean serum testosterone concentration in the patients with endometriosis was reported to be significantly lower than that without endometriosis. Our study was designed to investigate the influence of basal serum testosterone levels on the clinical outcome of in vitro fertilization (IVF) in the patients with III\u2010IV stage endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included 407 patients with III\u2010IV stage endometriosis diagnosed by laparoscopic surgery. We studied the association of the basal serum testosterone level and the reproductive outcome of IVF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The basal serum testosterone concentration was significantly higher in the pregnant group of patients with III\u2010IV stage endometriosis. The further analyses demonstrated that the implantation rate of the basal serum testosterone concentration\u2009&lt;\u20090.305\u2009ng\/mL group was significantly lower than the testosterone\u2009\u2265\u20090.305\u2009ng\/mL group (24.1% vs. 32.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). The clinical pregnancy and live birth rate of the basal serum testosterone &lt;\u20090.305\u2009ng\/mL group were also lower than that of the testosterone \u2265\u20090.305\u2009ng\/mL group. Both initial and total dose of gonadotropins in the testosterone &lt;0.305\u2009ng\/mL group are significantly higher than that of the testosterone \u22650.305\u2009ng\/mL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated, for the first time, that the basal serum testosterone &lt;0.305\u2009ng\/mL had an adverse impact on pregnancy outcomes of IVF\u2010embryo transfer in the patients with III\u2010IV stage endometriosis. Besides, the basal serum testosterone is also helpful in making individual stimulation protocol for the patients with advanced endometriosis before entering IVF cycles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14791","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T22:57:27Z","timestamp":1617663447000},"page":"2166-2174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low basal serum testosterone level is detrimental to the embryo implantation in the patients with severe endometriosis"],"prefix":"10.1111","volume":"47","author":[{"given":"Ling","family":"Huang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Reproductive Medicine  Guangzhou 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