{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T09:16:51Z","timestamp":1720516611596},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T00:00:00Z","timestamp":1628380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The molecular features of high\u2010grade endometrioid carcinoma (HGEC) are more akin to nonendometrioid high\u2010grade carcinoma (NEHC). This study aims to explore whether HGEC also has similar clinical pathology and prognosis similar to NEHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the SEER database (Surveillance, Epidemiology, and End Results), a retrospective study of the clinical\u2010pathological data and prognosis was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>(1) Compared with LGEC (low\u2010grade endometrioid carcinoma), HGEC patients were older with larger tumor size and a higher proportion of stage III\u2013IV disease. However, the young had a lower proportion of stage III\u2013IV disease than NEHC. (2) Postoperative pathological examination revealed that the positive rate of peritoneal cytology, pelvic lymph nodes and para\u2010aortic lymph nodes in HGEC were significantly higher than LGEC, but lower than NEHC. LGEC, HGEC, and NEHC, all showed distant organ metastases such as brain metastases, bone metastases, liver metastases, and lung metastases. Notably, the metastasis rates between HGEC and NEHC were not significantly different but were higher than LGEC. (3) The five\u2010overall survival rates of LGEC, HGEC, and NEHC were 95.1%, 73.2%, and 54.8%, respectively. Notably, the survival rates decreased significantly in stage IV. There were no significant differences between HGEC and NEHC in stage IV (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.665) and both were associated with worsened survival. Also, HGEC survival prognosis was similar to NEHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HGEC presents mixed or overlapping clinical\u2013pathological features of NEHC. Therefore, based on the unique pathological and prognostic features, HGEC could be classified as an intermediate between LGEC and NEHC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14839","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T23:49:45Z","timestamp":1628466585000},"page":"3644-3651","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical pathological characteristics and survival of high\u2010grade endometrioid carcinoma"],"prefix":"10.1111","volume":"47","author":[{"given":"Shuang","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecological Minimal Invasive Center Beijing Obstetrics 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