{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T15:45:34Z","timestamp":1725378334777},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein report a case of ovarian clear cell carcinoma with an immature teratoma component that exhibited aggressive behavior. A 47\u2010year\u2010old woman presented with abdominal distention, and computed tomography detected a cystic mass on the right ovary. The resected mass had mural nodules, most of which showed a pale\u2010yellow appearance; some nodules had a heterogeneous cut surface with bright yellow and white areas. Histologically, the former nodules were composed of clear cell carcinoma, while the latter contained teratomatous tissues, such as immature skeletal muscle, adipose tissue, and enteric glands. The tumor was staged as pT1c. Despite adjuvant chemotherapy and additional lymph node dissection, she had local recurrence and multiple liver metastasis 6\u00a0months after the first surgery. The disease rapidly progressed, and she died 9\u00a0months after the first surgery. Clear cell carcinoma and immature teratoma both showed ARID1A deficiency and an identical <jats:italic>PIK3CA<\/jats:italic> mutation, which suggested their clonal relationship.<\/jats:p>","DOI":"10.1111\/jog.14864","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:26:26Z","timestamp":1623284786000},"page":"3401-3407","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ovarian clear cell carcinoma with an immature teratoma component showing <scp>ARID1A<\/scp> deficiency and an identical <scp><i>PIK3CA<\/i><\/scp> mutation"],"prefix":"10.1111","volume":"47","author":[{"given":"Atsushi","family":"Kihara","sequence":"first","affiliation":[{"name":"Department of Pathology Jichi Medical University  Tochigi Japan"},{"name":"Department of Pathology Saitama Cancer Center  Saitama 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