{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:41:58Z","timestamp":1757540518650,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to determine the frequency of possible missed diagnosis of gestational trophoblastic disease in nonviable pregnancies and to evaluate the importance of histopathological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, the results of the histopathological assessment of patients undergoing uterine surgery with a diagnosis of nonviable pregnancy were analyzed before 14\u2009weeks of gestation. Nonviable pregnancy was defined as anembryonic pregnancy and intrauterine exitus (IU\u2010ex) based on ultrasound findings. The frequency and sonographic characteristics of molar pregnancy in nonviable pregnancy were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Molar pregnancy was detected in 24 (1.62%) of 1481 patients diagnosed with nonviable pregnancy on ultrasound. One thousand one hundred and twenty\u2010one of the cases were IU\u2010ex (75.69%) and the remaining were anembryonic pregnancy (24.31%). The mean crown\u2010rump length of pregnancies in the IU\u2010ex group was 16.7\u2009mm and the mean gestational age was 8\u2009weeks. The average gestational sac diameter was found to be 26\u2009mm in anembryonic pregnancy patients. The hydatidiform mole ratio was significantly higher in anembryonic pregnancy patients (3.06%) than in IU\u2010ex patients (1.16%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The appearance of early molar pregnancy on ultrasound evaluation may mimic anembryonic pregnancies. Therefore, histopathological examination of anembryonic pregnancies may be useful in early diagnosis and for the treatment of gestational trophoblastic neoplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14867","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T23:39:44Z","timestamp":1622072384000},"page":"2745-2751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histopathological examination of the curettage material in nonviable pregnancies and evaluation of the frequency of hydatidiform mole"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-033X","authenticated-orcid":false,"given":"Gulsah","family":"Dagdeviren","sequence":"first","affiliation":[{"name":"Department of Perinatology Etlik Zubeyde Hanim Women's Health Care, Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-7112","authenticated-orcid":false,"given":"Funda","family":"Cevher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gazi University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-1408","authenticated-orcid":false,"given":"Busra","family":"Cendek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Etlik Zubeyde Hanim Women's Health Care, Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-8552","authenticated-orcid":false,"given":"Salim","family":"Erkaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Etlik Zubeyde Hanim Women's Health Care, Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"National Guideline Alliance (UK).Ectopic pregnancy and miscarriage: diagnosis and initial management. 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