{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:40Z","timestamp":1747186540051,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>There is strong evidence that weekly intramuscular (IM) injections of 250\u2009mg of 17\u2010alpha\u2010hydroxyprogesterone caproate (17\u2010OHPC) reduce the risk of recurrent preterm birth (PTB); however, whether a lower dose of 17\u2010OHPC could reduce the risk of recurrent PTB remains unclear. This study aimed to assess whether 125\u2009mg of 17\u2010OHPC reduces recurrent PTB among women with a prior singleton spontaneous PTB and cervical length &gt;25\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study at a tertiary\u2010care medical center in Japan included women with a prior singleton spontaneous PTB between 20 and 36\u2009weeks' gestation and cervical length &gt;25\u2009mm, between 2008 and 2018. Primary outcomes were PTB &lt;37 and &lt;34\u2009weeks' gestation. We calculated the adjusted odds ratio (aOR) and 95% confidence interval (CI) using a multiple logistic regression model. Gestational age at delivery was compared using the Kaplan\u2013Meier survival curve and log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 173 women met the inclusion criteria. Eighty\u2010four women received weekly injections of 125\u2009mg of 17\u2010OHPC, and 89 did not. Treatment with 125\u2009mg of 17\u2010OHPC significantly reduced the risk of recurrent spontaneous PTB &lt;37 (aOR: 0.156 [95% CI: 0.049\u20130.497]) and &lt;34\u2009weeks' gestation (aOR: 0.156 [95% CI: 0.049\u20130.497]). The mean delivery gestational age was also significantly longer in the 17\u2010OHPC group (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study population, weekly IM injections of 125\u2009mg of 17\u2010OHPC reduced the risk of recurrent PTB &lt;37 and &lt;34\u2009weeks' gestation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14903","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T01:14:17Z","timestamp":1625447657000},"page":"3119-3126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventing recurrent preterm birth with 125\u2009mg of 17\u2010alpha\u2010hydroxyprogesterone caproate"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-389X","authenticated-orcid":false,"given":"Toma","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo","family":"Kyozuka","sequence":"additional","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiya","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of the Obstetrics and Gynecology, School of Medicine Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.246.27"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.843"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706475"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31593-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2017.01.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000275287.08520.4a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.01.039"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12940"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.02.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.02.019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.09.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.10.1097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0719"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182723b1b"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400227"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.048"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600949829"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.02.044"},{"key":"e_1_2_8_21_1","first-page":"401","article-title":"Pharmacological use of progesterone and 17\u2010alpha\u2010hydroxyprogesterone caproate in the prevention of preterm delivery","volume":"61","author":"Facchinetti F","year":"2009","journal-title":"Minerva Ginecol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00653.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085071"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719109340926"},{"key":"e_1_2_8_25_1","first-page":"19","article-title":"Insulin and insulin resistance","volume":"26","author":"Wilcox G","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003115"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115472"},{"key":"e_1_2_8_29_1","first-page":"CD010443","article-title":"Combined diet and exercise interventions for preventing gestational diabetes mellitus","volume":"11","author":"Shepherd E","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015402"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:09:37Z","timestamp":1693354177000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,4]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jog.14903"],"URL":"https:\/\/doi.org\/10.1111\/jog.14903","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2021,7,4]]},"assertion":[{"value":"2020-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}