{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:33:48Z","timestamp":1781246028604,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the relationship between excessive gestational weight gain during the week prior to delivery (GWG) and severe morbidity and pregnancy termination among pregnant women with preeclampsia (hypertension with proteinuria).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared GWG, laboratory data, and complication(s) between 94 preeclamptic women (preeclampsia group) with singleton pregnancies who delivered at \u226522 gestational weeks and 188 healthy women (control group) with singleton pregnancies undergoing elective cesarean deliveries. The gestational weeks at delivery were matched in the preeclampsia and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 282 total participants, median of GWG was significantly higher in the preeclampsia group than in the control group (1.6\u00a0kg vs. 0.5\u2009kg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Furthermore, the GWG cutoff value for the preeclampsia group was 1.6\u00a0kg. The odds ratio for morbidity of preeclampsia among the women with GWG \u22651.6\u00a0kg at delivery was 12.5 (95% confidence interval, 6.31\u201324.5). In the preeclampsia group, 47 women with GWG \u22651.6\u00a0kg had significantly higher risks of hypoproteinemia, proteinuria, and renal dysfunction than those of 47 women with GWG\u2009&lt;\u20091.6\u00a0kg. While, multivariate analysis showed 1.5\u00a0kg was a GWG cutoff value for predicting maternal morbidity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001); preeclamptic women with GWG \u22651.5\u00a0kg had a significantly higher risk of pulmonary edema than preeclamptic women with GWG\u2009&lt;\u20091.5\u00a0kg (odds ratio, 7.77; 95% confidence interval, 1.64\u201336.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excessive GWG in women with preeclampsia might be a predictor for severe maternal life\u2010threatening complications requiring pregnancy termination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14933","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T01:04:09Z","timestamp":1626138249000},"page":"3498-3508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Excessive gestational weight gain during the week prior to delivery as a predictor of maternal life\u2010threatening complications in preeclamptic women"],"prefix":"10.1111","volume":"47","author":[{"given":"Mamoru","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Mayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwamu","family":"Noshiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinuko","family":"Nakagawa\u2010Akabane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Umazume","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemichi","family":"Watari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003114"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174246"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00011-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01191.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.05.004"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Outline of the new definition and classification of \u201cHypertensive Disorders Of Pregnancy (HDP)\u201d; a revised JSSHP statement of 2005","volume":"14","author":"Watanabe K","year":"2018","journal-title":"Hypertens Res Pregnancy"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12419"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.14390\/jsshp.1.3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.049"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01254.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0211"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.05.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.12.013"},{"key":"e_1_2_8_16_1","first-page":"940","volume-title":"Section 12. Medical and surgical complications. Chapter 47. Critical care and trauma. Acute pulmonary edema. 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