{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:58:45Z","timestamp":1780592325082,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["19FC1006"],"award-info":[{"award-number":["19FC1006"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["20DA1010"],"award-info":[{"award-number":["20DA1010"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of noninvasive prenatal testing (NIPT) in high\u2010risk pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women who underwent GeneTech NIPT, the most commonly used NIPT in Japan, between January 2015 and March 2019, at Japan NIPT Consortium medical sites were recruited for this study. The exclusion criteria were as follows: pregnant women with missing survey items, multiple pregnancy\/vanishing twins, chromosomal abnormalities in the fetus other than the NIPT target disease, and nonreportable NIPT results. Sensitivity and specificity were calculated from the obtained data, and maternal age\u2010specific PPV and NPV were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 45\u2009504 cases, 44\u2009263 cases fulfilling the study criteria were included. The mean maternal age and gestational weeks at the time of procedure were 38.5\u2009years and 13.1\u2009weeks, respectively. Sensitivities were 99.78% (95% confidence interval [95% CI]: 98.78\u201399.96), 99.12% (95% CI: 96.83\u201399.76), and 100% (95% CI: 88.30\u2013100) for trisomies 21, 18, and 13, respectively. Specificities were more than 99.9% for trisomies 21, 18, and 13, respectively. Maternal age\u2010specific PPVs were more than 93%, 77%, and 43% at the age of 35\u2009years for trisomies 21, 18, and 13, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The GeneTech NIPT data showed high sensitivity and specificity in the detection of fetal trisomies 21, 18, and 13 in high\u2010risk pregnant women, and maternal age\u2010specific PPVs were obtained. These results could provide more accurate and improved information regarding NIPT for genetic counseling in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14954","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T20:40:23Z","timestamp":1628196023000},"page":"3437-3446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory"],"prefix":"10.1111","volume":"47","author":[{"given":"Yuna","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Medical Ethics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuko","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Suzumori","sequence":"additional","affiliation":[{"name":"Division of Clinical and Molecular Genetics, Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Tokushima Faculty of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Hasuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Hospital Organization Kyushu Medical Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fujita Health University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University School of Medicine  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Hamanoue","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Yokohama City University Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimune","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, School of Medicine Iwate Medical University  Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kamei","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Saitama Medical University School of Medicine  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Sawai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyonori","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Perinatal Medical Center Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Tairaku","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Sanui","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Fukuoka University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Mizuuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Osaka Women's and Children's Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Sanno Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology, Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Okayama University Graduate School of Medicine  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Murotsuki","sequence":"additional","affiliation":[{"name":"Department of Maternal and Fetal Medicine Tohoku University Graduate School of Medicine, Miyagi Children's Hospital  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuhei","family":"Kurashina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Samura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Maeda","sequence":"additional","affiliation":[{"name":"Perinatal medical center Shikoku Medical Center for Children and Adults  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Neki","sequence":"additional","affiliation":[{"name":"Division of Counseling for Medical Genetics National Cerebral and Cardiovascular Center  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Hamajima","sequence":"additional","affiliation":[{"name":"Division of Clinical Genetics and Genomics Nagoya City University West Medical Center  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Toho University Omori Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichiro","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokai University School of Medicine  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Center Aiiku Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Miharu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hiroshima Red Cross Hospital and Atomic\u2010Bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Yokohama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Asahikawa Medical University  Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Hirose","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Hyogo Prefectural Amagasaki General Medical Center  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Kokura Medical Center National Hospital Organization  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotake","family":"Ichizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Showa University Northern Yokohama Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Yamaguchi Prefectural Grand Medical Center  Yamagichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Reproduction Center Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Shiga","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Gifu University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Tashima","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Kansai Rosai Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Taketani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University  Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Japanese Red Cross Kyoto Daiichi Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Hamada","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Adachi Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fukushima Medical University  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Division of Clinical Genetics Tottori University Hospital  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadahiko","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Center for Molecular Medicine Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Katsura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Shiga University of Medical Science  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Ikenoue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Kochi University  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology International University of Health and Welfare Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Egawa","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolism in Cardiovascular Disease, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kasamatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kansai Medical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe Adventist Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology AOI Nagoya Hospital  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Kuji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Morisaki","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Sakakibara Heart Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Tanigaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Aichi Children's Health and Medical Center  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mitsubishi Kyoto Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ibaraki Prefectural Central Hospital  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mito Saiseikai General Hospital  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiki","family":"Hirahara","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Yokohama City University Hospital  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2013Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan N. I. P. T. Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13373"},{"key":"e_1_2_9_3_1","unstructured":"MaterniT\u00ae21PLUS. [cited 27 Nov 2020.] Available from:https:\/\/www.integratedgenetics.com\/providers\/tests\/prenatal\/nipt\/maternit21plus"},{"key":"e_1_2_9_4_1","unstructured":"GeneTech Inc. [cited 27 November 2020.] Available from:https:\/\/www.genetech.co.jp\/featurea\/"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4608"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.97"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4766"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-018-0453-8"},{"key":"e_1_2_9_9_1","unstructured":"The Japan Society of Obsterics and Gynecology. Policy statement on new noninvasive prenatal testing of fetal aneuploidy using maternal blood [cited 28 Jun 21] Available from:http:\/\/www.jsog.or.jp\/news\/pdf\/NIPT_shishin.pdf(in Japanese)"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824fb482"},{"key":"e_1_2_9_11_1","unstructured":"Bhatt S Parsa S Snyder H et al. Clinical laboratory experience with noninvasive prenatal testing: update on clinically relevant metrics. ISPD 2014 Oral Poster Session 1 P\u201055 [cited 2 Aug 2021.] Available from:https:\/\/www.ispdhome.org\/docs\/ISPD\/Conference\/ISPD_IC2014_Program_web.pdf"},{"key":"e_1_2_9_12_1","unstructured":"Analytical validation of the Verifi prenatal test: Enhanced test performance for detecting trisomies 21 18 and 13 and the option for classification of sex chromosome status. Illumina White Paper 2012."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182368a0e"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.73"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000363"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442931"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.08.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4686"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4539"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264259"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00283670"},{"key":"e_1_2_9_24_1","first-page":"743","article-title":"A simple function for maternal\u2010age\u2010specific rates of Down syndrome in the 20\u2010to\u201049\u2010year age range and its biological implications","volume":"32","author":"Lamson SH","year":"1980","journal-title":"Am J Hum Genet"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100380050046"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418391"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00276595"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-013-0010-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0485-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043693"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004084"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.10.050"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.29"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311037"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407349"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14792"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1481033"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:32:38Z","timestamp":1693225958000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jog.14954"],"URL":"https:\/\/doi.org\/10.1111\/jog.14954","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]},"assertion":[{"value":"2021-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}