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Data were calculated and presented by frequency and percentage, mean\u2009\u00b1\u2009standard deviation (SD), and median (range), respectively. Kaplan\u2013Meier survival analysis was performed to estimate overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finally, 34 studies including 40 ovarian cancer cases receiving chemotherapy during pregnancy were included. All 40 patients received chemotherapy during pregnancy. During the follow\u2010up, seven of 37 (18.9%) women had a relapse and four of them (4\/7, 57.1%) died of recurrence. Survival analysis failed to reach median OS and PFS within the follow\u2010up (range 3\u201372\u2009months). Better OS and PFS after chemotherapy in pregnancy were obtained in women with early\u2010stage ovarian cancer (I) compared with those with advanced stage (III\u2013IV). Neither OS nor FS differed between women treated with multi\u2010drugs and those with monotherapy. Forty\u2010one newborns were delivered from 40 pregnant women. Thirty\u2010four (34\/41, 82.9%) were completely healthy at birth and the end of follow\u2010up (range 0.18\u2013160\u2009months). However, one newborn died 5\u2009days after birth due to multiple congenital malformations, and another one developed Tourette's syndrome, aphasia, Asperger's syndrome as well as speech delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis first reveals the efficacy and safety of chemotherapy for ovarian cancer during pregnancy, especially for early\u2010stage patients. Cisplatin or carboplatin is suggested to be used as monotherapy to reduce adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14957","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T04:08:06Z","timestamp":1627963686000},"page":"3425-3436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chemotherapy for ovarian cancer during pregnancy: A systematic review and meta\u2010analysis of case reports and series"],"prefix":"10.1111","volume":"47","author":[{"given":"Xingzhi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ningbo Huamei Hospital, University of Chinese Academy of Sciences  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxue","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ningbo Huamei Hospital, University of Chinese Academy 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