{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:04:56Z","timestamp":1783699496467,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present a case of congenital toxoplasmosis (TXP) in a woman with <jats:italic>Toxoplasma gondii<\/jats:italic> infection more than 6\u00a0months before conception. The woman has been treated with adalimumab for ankylosing spondylitis for 4\u2009years until 5\u2009months before conception. TXP serology at the first trimester was compatible with infection prior pregnancy. An ultrasound performed at 26\u2009weeks gestation (WG) showed cerebral echogenic lesions compatible with intrauterine infection. Amniocentesis was performed which confirmed TXP fetal infection. Termination of the pregnancy was performed upon parent's requests and the fetal autopsy confirmed the diagnosis. Here, we discuss the potential role of immunosuppressive treatments, such as adalimumab, in the risk of congenital toxoplasmosis and the importance of counseling before pregnancy.<\/jats:p>","DOI":"10.1111\/jog.14973","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T05:21:32Z","timestamp":1628745692000},"page":"4055-4059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Congenital toxoplasmosis after adalimumab treatment before pregnancy"],"prefix":"10.1111","volume":"47","author":[{"given":"Elo\u00efse","family":"Krull","sequence":"first","affiliation":[{"name":"Obstetrics Service, Department of Pediatrics, Gynecology, and Obstetrics Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Taraschi","sequence":"additional","affiliation":[{"name":"Obstetrics Service, Department of Pediatrics, Gynecology, and Obstetrics Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle Boffi","family":"El Amari","sequence":"additional","affiliation":[{"name":"Private Practice  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Pellegrinelli","sequence":"additional","affiliation":[{"name":"Obstetrics Service, Department of Pediatrics, Gynecology, and Obstetrics Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Martinez de Tejada","sequence":"additional","affiliation":[{"name":"Obstetrics Service, Department of Pediatrics, Gynecology, and Obstetrics Geneva University Hospitals  Geneva Switzerland"},{"name":"Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Toxoplasmosis during pregnancy and infancy. 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