{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:30:46Z","timestamp":1786815046371,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["9728"],"award-info":[{"award-number":["9728"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between Hox transcript antisenses RNA (HOTAIR) polymorphisms, rs12826786 C\/T, rs920778 T\/C, rs4759314 A\/G, and rs1899663 G\/T, with recurrent spontaneous abortion (RSA) susceptibility in the Iranian women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 161 patients diagnosed with RSA and 177 healthy women with at least one live birth without a history of abortion. Genotyping of <jats:italic>HOTAIR<\/jats:italic> polymorphisms was carried out using both restriction fragment length polymorphism\u2010polymerase chain reaction and amplification refractory mutation system\u2010polymerase chain reaction methods. Odds ratios (ORs) with 95% confidence intervals (CIs) were assessed to estimate the strength of association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Different inheritance models of rs12826786 C\/T, rs920778 T\/C, and rs1899663 G\/T polymorphisms significantly enhanced the risk of RSA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), whereas the rs4759314 A\/G polymorphism was correlated with diminished risk of developing RSA under recessive AA versus GA\u2009+\u2009GG (OR 0.42 [95% CI\u00a0=\u00a00.19\u20130.91]), log\u2010additive GG versus GA vs. GG (OR 0.67 [95%\u00a0CI\u00a0=\u00a00.48\u20130.93]), and allelic A versus G (OR 0.65 [95%\u00a0CI\u00a0=\u00a00.47\u20130.92]) models. Moreover, the TGTC, TTCT, TTTC, CGTC, CGTT, CTCC, CTCT, CTTC, and CTTT haplotypes of rs920778\/rs1899663\/rs12826786\/ significantly increased the risk of RSA. The studied variants were not in strong linkage disequilibrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicated that variations in the <jats:italic>HOTAIR<\/jats:italic> gene might serve as beneficial biomarkers for determining susceptibility to RSA. To confirm these findings, replication studies with a larger population and different races are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14977","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T01:34:45Z","timestamp":1629077685000},"page":"3767-3778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic variants of <scp><i>HOTAIR<\/i><\/scp> are associated with susceptibility to recurrent spontaneous abortion: A preliminary case\u2013control study"],"prefix":"10.1111","volume":"47","author":[{"given":"Saeedeh","family":"Salimi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry School of Medicine, Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Cellular and Molecular Research Center Resistant Tuberculosis Institute, Zahedan University of Medical Sciences  Zahedan 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University of Medical Sciences  Zahedan Iran"},{"name":"Moloud Infertility Center Ali Ibn Abitaleb Hospital, Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.11.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2003.04.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0124"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.9.4261"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.10.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429450303-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2011-0313"},{"key":"e_1_2_9_9_1","first-page":"277","article-title":"HLA\u2010G and HLA\u2010E Gene 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