{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:28:58Z","timestamp":1784237338386,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the survival outcome between radical hysterectomy and simple hysterectomy with radiation therapy in patients with stage II endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a retrospective cohort study based on the SEER database from January 1, 1988 to December 31, 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 577 patients were enrolled in the study, 117 patients received radical hysterectomy and 460 patients received simple hysterectomy combined with vaginal brachytherapy. All patients received external beam radiation therapy after the surgery. The median follow\u2010up duration was 82.77\u2009\u00b1\u20091.44\u2009months. No differences were found on the baseline information between two groups. Both the 5\u2010year overall survival (62.31% vs. 78.48%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 5\u2010year cause\u2010specific survival (74.60 vs. 85.38%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) were shorter in radical hysterectomy than in simple hysterectomy combined with vaginal brachytherapy group. However, the positive outcomes were further validated in patients with high\u2010risk endometrial cancer, not in patients with grade 1\u20132 low\u2010risk endometrial cancer both on cause\u2010specific survival and overall survival. In patients with grade 3 low\u2010risk endometrial cancer, the tendency was only found with lower overall survival not cause\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study revealed that in patients' high\u2010risk stage II endometrial cancer, radical hysterectomy was associated with shorter survival outcome than simple hysterectomy combined with vaginal brachytherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14988","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T04:11:31Z","timestamp":1629346291000},"page":"3943-3950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Radical hysterectomy versus simple hysterectomy and brachytherapy for stage <scp>II<\/scp> endometrial cancer"],"prefix":"10.1111","volume":"47","author":[{"given":"Ming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beijing Youan Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-8408","authenticated-orcid":false,"given":"Yumei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Beijing Obstetrics and Gynecology Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2018.01.01"},{"key":"e_1_2_8_4_1","unstructured":"The American College of Obstetrics and Gynecologists(2014)Morcellation and Occult Malignancy in Gynecologic Surgery.Available at:http:\/\/www.sgo.org\/wp-content\/uploads\/2014\/04\/ACOG_Statement.pdf"},{"key":"e_1_2_8_5_1","first-page":"413","article-title":"Practice bulletin, clinical management guidelines for obstetrician\u2010gynecologists number 61, August 2005: management of endometrial cancer","volume":"105","author":"ACOG","year":"2005","journal-title":"Am Coll Obstet Gynecol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1993.1297"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.01061.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.12.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000260871.87607.25"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5501"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.521"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001133"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5372-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07472-y"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0123"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.10.026"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.04.036"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.07.005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2016.11.005"},{"key":"e_1_2_8_20_1","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results Program.Cancer statistics. 2019. 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