{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:56:08Z","timestamp":1772502968680,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies provided inconsistent results regarding the association between inflammatory bowel disease (IBD) and risk of abnormalities of uterine cervix. The study aimed to make a meta\u2010analysis to evaluate the association between IBD and risk of abnormalities of uterine cervix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Articles published until April 2021 and regarding the association between IBD and risk of abnormalities of uterine cervix were searched in the following databases: PubMed, Web of Science, EMBASE, Medline, and Google Scholar. Odds ratios (ORs) from case\u2013control studies and relative risks (RRs) from cohort studies with their 95% confidence intervals (CIs) were computed to generate a pooled effect size and 95% CI using STATA 12.0 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present study finally included seven cohort studies (including 94\u2009144 IBD patients and 53\u2009661\u2009004 HC) and four case\u2013control studies (including 20\u2009267 cases and 60\u2009034 matched controls). The meta\u2010analysis indicated a positive association between IBD and risk of abnormalities of uterine cervix with a random\u2010effects model (OR\/RR\u00a0=\u00a02.46, 95% CI 1.55\u20133.91, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a091.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). However, no significant association between IBD and risk of cervical cancer was showed in the study with a random\u2010effects model (OR\/RR\u00a0=\u00a01.54, 95% CI 0.83\u20132.85, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a082.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, IBD is associated with a 146% higher risk of abnormalities of uterine cervix. However, the study demonstrated no significant association between IBD and risk of cervical cancer. Thus, a conventional screening for abnormalities of uterine cervix is essential for IBD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14992","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T05:05:26Z","timestamp":1631768726000},"page":"4030-4036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between inflammatory bowel disease and risk of abnormalities of uterine cervix"],"prefix":"10.1111","volume":"47","author":[{"given":"Yuemei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Dalian Municipal Central Hospital, Affiliated of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Dalian Municipal Central Hospital, Affiliated of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Dalian Municipal Central Hospital, Affiliated of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-1606","authenticated-orcid":false,"given":"Lifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Dalian Municipal Central Hospital, Affiliated of Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06005"},{"key":"e_1_2_8_3_1","first-page":"92","article-title":"Cervical intraepithelial neoplasia and human papilloma virus infection in renal transplant 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