{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:10:45Z","timestamp":1776993045203,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the significance of zinc supplementation for zinc deficiency during chemotherapy for gynecologic malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight patients suspected of zinc deficiency before chemotherapy were prospectively evaluated. Gustatory test, serum zinc, blood count, and biochemical examinations were made pre\u2010chemotherapy at 3\u2010 and 6\u2010week intervals. Patients with serum zinc levels &lt;70\u2009\u03bcg were prescribed oral zinc acetate hydrate (167.8\u00a0mg\/day) for 3\u2009weeks. The primary outcome was efficacy of zinc supplementation, the secondary outcomes were zinc deficiency rates and adverse effects of the zinc supplement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen (mean serum zinc level: 67.4\u2009\u00b1\u20096.2\u00a0\u03bcg\/dL) out of 28 patients were administered zinc supplementation pre\u2010chemotherapy, and subsequent serum zinc levels reached 83.2\u2009\u00b1\u200915.3\u00a0\u03bcg\/dL in 3\u2009weeks. Factors associated with chemotherapy (vs. chemoradiation, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041) and taxane + platinum (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.048) were significant risk factors for decreasing zinc levels following chemotherapy. Although patients that required zinc supplementation showed decreased serum zinc levels after chemotherapy and tended to experience taste alteration (sour: <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041), zinc supplementation for zinc deficiency during chemotherapy did not alter taste perception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Zinc supplementation promptly increased serum levels without major complications and may prevent an alteration in taste perception.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14996","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T23:30:16Z","timestamp":1630884616000},"page":"3998-4004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zinc supplementation during chemotherapy for gynecological malignancy"],"prefix":"10.1111","volume":"47","author":[{"given":"Shintaro","family":"Yanazume","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ushiwaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honami","family":"Yorouki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohisa","family":"Onigahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-9405","authenticated-orcid":false,"given":"Shinichi","family":"Togami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-333X","authenticated-orcid":false,"given":"Masaki","family":"Kamio","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2491-2189","authenticated-orcid":false,"given":"Hiroaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050568"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000343368.06247.74"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0333"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20347"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-016-0836-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.07.017"},{"key":"e_1_2_7_8_1","first-page":"120","article-title":"Practice guideline for zinc deficiency","volume":"40","author":"Kodama H","year":"2018","journal-title":"J Jpn Soc Clin Nutr"},{"key":"e_1_2_7_9_1","first-page":"CD010470","article-title":"Interventions for managing taste disturbances","volume":"12","author":"Kumbargere Nagraj S","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_10_1","first-page":"1071","article-title":"The method of gustatory test by filter paper disc","volume":"83","author":"Okuda Y","year":"1980","journal-title":"J Otolaryngol Jpn"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.2690"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980515)82:10<1938::AID-CNCR18>3.0.CO;2-U"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2012.676618"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12995"},{"key":"e_1_2_7_15_1","first-page":"870","article-title":"Prevention and treatment of hypogeusia due to head and neck irradiation","volume":"220","author":"Henkin RI","year":"1972","journal-title":"JAMA"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.09.015"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14996","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:29:32Z","timestamp":1692977372000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,5]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jog.14996"],"URL":"https:\/\/doi.org\/10.1111\/jog.14996","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,5]]},"assertion":[{"value":"2021-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}