{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:31:11Z","timestamp":1762918271695,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To evaluate the efficacy, tolerability, and cost of four commonly prescribed oral iron preparations: ferrous sulfate (FS), ferrous fumarate (FF), ferrous ascorbate (FA), and carbonyl iron (CI) in the treatment of iron\u2010deficiency anemia (IDA) in pregnant women.<\/jats:p><\/jats:sec>Methods<\/jats:title>It was a prospective, randomized, open\u2010label, blinded endpoint (PROBE) design with four parallel active control groups: FS, FF, FA, CI. The primary outcome was the proportion of participants becoming non\u2010anemic (Hb\u2009\u2265\u200911\u2009g%) at the end of the study period. The secondary outcomes were the proportion of participants achieving normal red blood corpuscular indices such as mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration; the proportion of participants achieving normal iron indices such as serum iron, serum ferritin, total iron\u2010binding capacity, and transferrin saturation; and comparison of incidence of any adverse events between treatment groups and comparison of costs of individual drug therapy between treatment groups.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred and twenty patients were randomized to four different groups (n<\/jats:italic>\u00a0=\u00a030). The results of the present study show that all the four iron salts at the dose of 200\u2009mg elemental iron per day were equally effective in improving hemoglobin concentration and other hematological parameters. The adverse effects were more common in the FF group (56.7%). The pharmacoeconomic analysis showed that all the drugs are equally cost\u2010effective.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>To conclude from the results of the present study, it can be said that FS, FF, FA, and CI are equally effective in treating IDA and they can be prescribed interchangeably.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14999","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T04:42:45Z","timestamp":1630989765000},"page":"3828-3841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A randomized controlled trial comparing the efficacy, tolerability, and cost of oral iron preparations in iron\u2010deficiency anemia in pregnancy"],"prefix":"10.1111","volume":"47","author":[{"given":"Nanda","family":"Gamad","sequence":"first","affiliation":[{"name":"Department of Pharmacology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradip Kumar","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Haematology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanita","family":"Suri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitava","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-7159","authenticated-orcid":false,"given":"Lekha","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_265_18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20163431"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_33_17"},{"key":"e_1_2_8_5_1","unstructured":"Ministry of Health and Family Welfare GoIGuidelines for prevention of maternal anaemia. 2014. [cited 2019 Jun 15]. Available from:http:\/\/www.nrhmtn.gov.in\/guideline\/RGPMA.pdf"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000034"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-018-0949-6"},{"key":"e_1_2_8_8_1","unstructured":"StoltzfusRJ DreyfussML International Nutritional Anemia Consultative Group (INACG).WHO Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia."},{"key":"e_1_2_8_9_1","first-page":"552","article-title":"Pregnancy induced iron deficiency and the evaluation and comparison of the efficacy and safety of ferrous fumarate and carbonyl iron in its treatment \u2013 PERFECT trial","volume":"59","author":"Smita S","year":"2009","journal-title":"J Obstet Gynecol India"},{"key":"e_1_2_8_10_1","first-page":"338","article-title":"Comparative assessment of the bioavailability, efficacy and safety of a modified\u2010release (MR) carbonyl iron tablet and oral conventional iron preparation in adult Indian patients with nutritional iron deficiency anaemia","volume":"103","author":"Adsul BB","year":"2005","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_8_11_1","first-page":"29","article-title":"Comparison of efficacy, tolerability, and cost of newer with conventional oral iron preparation","volume":"6","author":"Patil SS","year":"2013","journal-title":"Al Ameen J Med Sci"},{"key":"e_1_2_8_12_1","first-page":"47","article-title":"Comparison of efficacy, safety and cost of therapy with oral ferrous ascorbate and ferrous sulphate in patients with iron deficiency anemia","volume":"2","author":"Panchal PJ","year":"2014","journal-title":"J Drug Disc Ther"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women","volume":"9","author":"Saha L","year":"2007","journal-title":"MedGenMed"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2014\/3488"},{"key":"e_1_2_8_15_1","first-page":"132","article-title":"Comparative study of iron supplements: its efficacy and tolerability","volume":"4","author":"Pyarelal","year":"2015","journal-title":"Ind J Basic App Med Res"},{"key":"e_1_2_8_16_1","first-page":"339","article-title":"Pharmacoeconomic evaluation of ferrous ascorbate, ferrous fumarate and iron polymaltose complex in 14 to 24\u2009weeks of gestation","volume":"5","author":"Angadi E","year":"2015","journal-title":"Int J Health Sci Res"},{"key":"e_1_2_8_17_1","first-page":"248","article-title":"Comparison of efficacy and safety profile of oral iron formulations in patients with iron deficiency anemia","volume":"41","author":"Panicker NK","year":"2016","journal-title":"Int J Pharm Sci Rev Res"},{"key":"e_1_2_8_18_1","first-page":"429","article-title":"A comparative study of use of preparation containing ferrous sulphate versus ferrous fumarate in treatment of iron deficiency anemia","volume":"1","author":"Bhoomi AD","year":"2010","journal-title":"Int J Pharm Biol Sci Arch"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14999","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:28:57Z","timestamp":1692977337000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,6]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jog.14999"],"URL":"https:\/\/doi.org\/10.1111\/jog.14999","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2021,9,6]]},"assertion":[{"value":"2021-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}