{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:30:01Z","timestamp":1792279801479,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Diabetes mellitus (DM) is a major complication in pregnancy. Placental lesions with DM remain unclear and controversial. Recently, the terms of placental pathological findings, such as maternal and fetal vascular malperfusions (MVM and FVM, respectively) were introduced by the Amsterdam Placental Workshop Group Consensus Statement (APWGCS). FVM cases were classified as the partial obstruction type (global FVM) and the complete obstruction type (segmental FVM). The aim of this study was to clarify the pathological characteristics of the placenta with pregestational DM\/gestational DM; GDM according to APWGCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the placentas of 182 DM women (27 pregestational DM and 155 GDM) and control placentas of 460 women without DM during 2011\u20132018. We excluded cases of intrauterine fetal death or multiple pregnancies. We reviewed microscopical findings including, MVM, FVM, chorioamnionitis with the slides according to the APWGCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microscopically, the incidence of FVM was significantly higher in GDM patients than control (17% vs. 10%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0138), but not significant in pregestational DM (11%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.7410). Segmental FVM (complete obstruction) was significantly more observed in GDM than control group (5% vs. 0.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0013). Segmental FVM in GDM showed high incidence of light\u2010for\u2010dates infant (three of seven cases, 43%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0288). In addition, several segmental FVM findings (villous stromal\u2010vascular karyorrhexis and stem vessel occlusion) were frequently noted in 2 or 3 points positive of 75\u2009g oral glucose tolerance test than 1 point positive GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our placental findings suggest disorder of carbohydrate metabolism might affect the fetal vascular damage, especially complete fetal vascular obstruction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15046","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T02:05:34Z","timestamp":1635905134000},"page":"80-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association between fetal vascular malperfusion and gestational diabetes"],"prefix":"10.1111","volume":"48","author":[{"given":"Tomoko","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1171-2620","authenticated-orcid":false,"given":"Yuichiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Faculty of Medicine, Miyazaki University Hospital University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-1473","authenticated-orcid":false,"given":"Yuki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Tomimori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine University of Miyazaki  Miyazaki 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