{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:34:39Z","timestamp":1747186479112,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ependymomas arise from ependymal cells lining the ventricles and central canal of the spinal cord and can occur throughout the whole neuraxis. The lesion rarely occurs in extracranial or extraspinal regions, particularly in the uterine broad ligament. Thus, for the pathogenesis of nonsacral extra\u2010central nervous system (CNS) ependymomas remains elusive. Here, we describe a rare case of primary uterine broad ligament. ependymoma with cell\u2010cycle\u2010checkpoint kinase 2 (<jats:italic>CHEK2<\/jats:italic>) <jats:italic>p.H371Y<\/jats:italic> germline mutation. A 45\u2010year\u2010old woman presented with a uterine mass. The transvaginal sonographic examination confirmed a 4.4\u00a0cm\u2009\u00d7\u20093.7\u00a0cm, cystic and solid, mass located on the right side uterine wall near isthmus. First, laparoscopy with the neoplasm resection was carried out. Based on morphological and immunohistochemical characteristics of tumor cells that expressed glial fibrillary acidic protein (<jats:italic>GFAP<\/jats:italic>), <jats:italic>S\u2010100<\/jats:italic>, and vimentin, the tumor was diagnosed as an ependymoma. After that, she underwent a laparotomic total hysterectomy, bilateral salpingo\u2010oophorectomy, and lymphadenectomy. Furthermore, we performed next\u2010generation sequencing (NGS) of the patient's resected tumor tissue and peripheral blood and identified a novel <jats:italic>CHEK2 p.H371Y<\/jats:italic> germline mutation. Following surgery, the patient received oral tamoxifen (10\u00a0mg 2\/day) and followed by letrozole (2.5\u00a0mg\/day) for 6 months. The patient remained disease\u2010free after 4\u2009years of follow\u2010up. Conceivably, <jats:italic>CHEK2 p.H371Y<\/jats:italic> is a driving gene for the development of extra\u2010CNS ependymoma.<\/jats:p>","DOI":"10.1111\/jog.15065","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T07:25:21Z","timestamp":1635578721000},"page":"266-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary uterine broad ligament ependymoma with <scp><i>CHEK2<\/i><\/scp><i>p.<scp>H371Y<\/scp><\/i> germline mutation: A <scp>CARE<\/scp>\u2010compliant case report uterine broad ligament ependymoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-7689","authenticated-orcid":false,"given":"Jiaxin","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Oncology The First Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongdi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology Jilin Cancer Hospital  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Hospital of Jilin University  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.4.719"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02509.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-1338-PEMEOT"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198403000-00006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891215)64:12<2565::AID-CNCR2820641226>3.0.CO;2-I"},{"key":"e_1_2_7_7_1","first-page":"291","article-title":"Ependymoma\u2010like tumor of the mesovarium","volume":"109","author":"Grody WW","year":"1985","journal-title":"Arch Pathol Lab 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