{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:20:37Z","timestamp":1767165637306,"version":"build-2238731810"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We aimed to investigate the value of follicular fluid fetuins\u2010A and \u2010B to predict successful IVF and pregnancy outcomes in infertile women with poor, normal, and high ovarian reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The follicular fluid of 96 infertile women who underwent intra\u2010cytoplasmic sperm injection (ICSI) procedure was analyzed. Fetuins\u2010A and \u2010B levels were examined and compared in those who could achieve pregnancy and those who could not. Receiver operating characteristic curve analyzes were used to determine cut\u2010off and statistically significant associations for fetuins\u2010A and \u2010B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Follicular fluid fetuin\u2010A levels were higher in cases with weak ovarian reserve (OR) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and higher in patients who did not achieve clinical pregnancy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Conversely, the follicular fluid fetuin\u2010B levels were lower in cases with poor OR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and were lower in patients who did not achieve a clinical pregnancy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). A follicular fluid fetuin\u2010A concentration\u2009\u2264\u200919.12\u2009ng\/mL had a sensitivity and specificity of 94.74% and 93.1%, respectively, at predicting clinical pregnancy. While the follicular fluid fetuin\u2010B concentration &gt;24.7\u00a0ng\/mL had sensitivity and specificity of 71.1% and 51.7%, respectively, for clinical pregnancy prediction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, high levels of follicular fluid fetuin\u2010A may be independently associated with unsuccessful IVF irrespective of OR grouping. A low level of follicular fetuin\u2010B was also associated with failed IVF. The sensitivity and specificity were found to be higher for fetuin\u2010A in predicting clinical pregnancy. Therefore, the follicular fluid fetuin\u2010A may be more predictive for successful IVF and clinical pregnancy outcomes than follicular fluid fetuin\u2010B.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15070","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T05:12:48Z","timestamp":1635397968000},"page":"178-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pred\u0131ct\u0131ve value of pregnancy of foll\u0131cular flu\u0131d\n                    <scp>fetu\u0131n\u2010A<\/scp>\n                    and \u2010B levels \u0131n infert\u0131le women after intra\u2010cytoplasmic sperm injection"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-043X","authenticated-orcid":false,"given":"Nazan","family":"Yurtcu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Sivas Cumhuriyet University  Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-6278","authenticated-orcid":false,"given":"Serkan","family":"Oral","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, Halic University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-1603","authenticated-orcid":false,"given":"Sebahattin","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Balikesir State Hospital  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-8454","authenticated-orcid":false,"given":"Suleyman Tumer","family":"Cal\u0131skan","sequence":"additional","affiliation":[{"name":"Department of Urology Samsun Gazi State Hospital  Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6744-1754","authenticated-orcid":false,"given":"Murat","family":"Alagoz","sequence":"additional","affiliation":[{"name":"In Vitro Fertilization Unit, Department of Obstetrics and Gynecology Medical Park Hospital  Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Dahan","sequence":"additional","affiliation":[{"name":"McGill University Reproductive Center  Montr\u00e9al Quebec 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